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  3. Serotonin is elevated in risk-genotype carriers of TCF7L2 - rs7903146.
 

Serotonin is elevated in risk-genotype carriers of TCF7L2 - rs7903146.

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BORIS DOI
10.7892/boris.135233
Date of Publication
September 6, 2019
Publication Type
Article
Division/Institute

Universitätsklinik fü...

Author
Leiherer, Andreas
Muendlein, Axel
Saely, Christoph H
Fraunberger, Peter
Drexel, Heinz
Universitätsklinik für Angiologie
Subject(s)

600 - Technology::610...

Series
Scientific reports
ISSN or ISBN (if monograph)
2045-2322
Publisher
Springer Nature
Language
English
Publisher DOI
10.1038/s41598-019-49347-y
PubMed ID
31492908
Description
The transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146 is known to be tightly associated with an elevated risk for type 2 diabetes, whereas the molecular mechanisms remain elusive. We evaluated the metabolic profile of a total of 394 patients' serum samples with respect to their rs7903146 genotype using targeted metabolomics in a discovery (n = 154) and a validation (n = 240) study. We have identified serotonin as the top metabolite being increased in carriers of the risk allele. Serotonin was significantly associated with the rs7903146 genotype after full adjustment including type 2 diabetes and further top ranked metabolites. Given the role of peripheral serotonin in metabolic homeostasis and type 2 diabetes, this finding provides a first hint that the well-known impact of the TCF7L2 polymorphism on type 2 diabetes risk may involve a serotonin-dependent pathway.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/183422
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Leiherer_Serotonin is elevated in risk-genotype carriers_ScientificReports.pdftextAdobe PDF1.17 MBAttribution (CC BY 4.0)publishedOpen
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