Serotonin is elevated in risk-genotype carriers of TCF7L2 - rs7903146.
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BORIS DOI
Date of Publication
September 6, 2019
Publication Type
Article
Division/Institute
Author
Leiherer, Andreas | |
Muendlein, Axel | |
Saely, Christoph H | |
Fraunberger, Peter |
Subject(s)
Series
Scientific reports
ISSN or ISBN (if monograph)
2045-2322
Publisher
Springer Nature
Language
English
Publisher DOI
PubMed ID
31492908
Description
The transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146 is known to be tightly associated with an elevated risk for type 2 diabetes, whereas the molecular mechanisms remain elusive. We evaluated the metabolic profile of a total of 394 patients' serum samples with respect to their rs7903146 genotype using targeted metabolomics in a discovery (n = 154) and a validation (n = 240) study. We have identified serotonin as the top metabolite being increased in carriers of the risk allele. Serotonin was significantly associated with the rs7903146 genotype after full adjustment including type 2 diabetes and further top ranked metabolites. Given the role of peripheral serotonin in metabolic homeostasis and type 2 diabetes, this finding provides a first hint that the well-known impact of the TCF7L2 polymorphism on type 2 diabetes risk may involve a serotonin-dependent pathway.
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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Leiherer_Serotonin is elevated in risk-genotype carriers_ScientificReports.pdf | text | Adobe PDF | 1.17 MB | Attribution (CC BY 4.0) | published |