Directional local field potentials: A tool to optimize deep brain stimulation.
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BORIS DOI
Date of Publication
January 2018
Publication Type
Article
Division/Institute
Contributor
Pogosyan, Alek | |
Shah, Syed Ahmar | |
Tan, Huiling | |
Brittain, John-Stuart | |
di Biase, Lazzaro | |
Brown, Peter |
Subject(s)
Series
Movement disorders
ISSN or ISBN (if monograph)
0885-3185
Publisher
Wiley-Blackwell
Language
English
Publisher DOI
PubMed ID
29150884
Uncontrolled Keywords
Description
BACKGROUND
Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.
OBJECTIVES
Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.
METHODS
Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.
RESULTS
Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.
CONCLUSION
Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.
OBJECTIVES
Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.
METHODS
Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.
RESULTS
Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.
CONCLUSION
Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| Tinkhauser_et_al-2017-Movement_Disorders.pdf | text | Adobe PDF | 560.88 KB | Attribution (CC BY 4.0) | published |