Older Candidates for Subthalamic Deep Brain Stimulation in Parkinson's Disease Have a Higher Incidence of Psychiatric Serious Adverse Events.
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BORIS DOI
Date of Publication
2016
Publication Type
Article
Division/Institute
Contributor
Cozac, Vitalii V | |
Ehrensperger, Michael M | |
Gschwandtner, Ute | |
Hatz, Florian | |
Meyer, Antonia | |
Monsch, Andreas U | |
Taub, Ethan | |
Fuhr, Peter |
Subject(s)
Series
Frontiers in aging neuroscience
ISSN or ISBN (if monograph)
1663-4365
Publisher
Frontiers Research Foundation
Language
English
Publisher DOI
PubMed ID
27375478
Uncontrolled Keywords
Description
OBJECTIVE
To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD).
METHODS
We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups.
RESULTS
A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01).
CONCLUSIONS
The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.
To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD).
METHODS
We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups.
RESULTS
A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01).
CONCLUSIONS
The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| fnagi-08-00132.pdf | text | Adobe PDF | 181.71 KB | Attribution (CC BY 4.0) | published |