Brain barriers: Crosstalk between complex tight junctions and adherens junctions
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BORIS DOI
Date of Publication
May 25, 2015
Publication Type
Article
Division/Institute
Subject(s)
Series
Journal of cell biology
ISSN or ISBN (if monograph)
0021-9525
Publisher
Rockefeller Institute Press
Language
English
Publisher DOI
PubMed ID
26008742
Description
Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crosstalk between adherens junctions and tight junctions in maintaining barrier integrity is an understudied area that may represent a promising target for influencing brain barrier function.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| JCB_201412147.pdf | text | Adobe PDF | 1.77 MB | Attribution-NonCommercial-ShareAlike (CC BY-NC-SA 4.0) | published |