Publication:
Brain barriers: Crosstalk between complex tight junctions and adherens junctions

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cris.virtual.author-orcid0000-0003-3059-9846
cris.virtualsource.author-orcideca93d01-2366-4c48-b32d-dade4750a69e
cris.virtualsource.author-orcid9afa0db9-fa00-4dc1-8e46-127545c2140a
datacite.rightsopen.access
dc.contributor.authorTietz, Silvia Martina
dc.contributor.authorEngelhardt, Britta
dc.date.accessioned2024-10-24T16:41:48Z
dc.date.available2024-10-24T16:41:48Z
dc.date.issued2015-05-25
dc.description.abstractUnique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crosstalk between adherens junctions and tight junctions in maintaining barrier integrity is an understudied area that may represent a promising target for influencing brain barrier function.
dc.description.numberOfPages14
dc.description.sponsorshipTheodor-Kocher-Institut (TKI)
dc.identifier.doi10.7892/boris.77329
dc.identifier.pmid26008742
dc.identifier.publisherDOI10.1083/jcb.201412147
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/139085
dc.language.isoen
dc.publisherRockefeller Institute Press
dc.relation.ispartofJournal of cell biology
dc.relation.issn0021-9525
dc.relation.organizationDCD5A442BF88E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleBrain barriers: Crosstalk between complex tight junctions and adherens junctions
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage506
oaire.citation.issue4
oaire.citation.startPage493
oaire.citation.volume209
oairecerif.author.affiliationTheodor-Kocher-Institut (TKI)
oairecerif.author.affiliationTheodor-Kocher-Institut (TKI)
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.description.ispublishedpub
unibe.eprints.legacyId77329
unibe.journal.abbrevTitleJ CELL BIOL
unibe.refereedtrue
unibe.subtype.articlereview

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