Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo
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BORIS DOI
Date of Publication
2011
Publication Type
Article
Division/Institute
Contributor
Abdollahi, Amir | |
Bischof, Marc | |
Gebhard, Martha-Maria | |
Ewerbeck, Volker | |
Huber, Peter E | |
Sckell, Axel |
Series
Strahlentherapie und Onkologie
ISSN or ISBN (if monograph)
0179-7158
Publisher
Springer-Medizin-Verlag
Language
English
Publisher DOI
PubMed ID
21234531
Description
Cyclooxygenase-2 (COX-2) inhibitors mediate a systemic antitumor activity via antiangiogenesis and seem to enhance the response of primary tumors to radiation. Radiosensitizing effects of COX-2 inhibition have not been reported for bone metastases. Therefore, the aim of this study was the investigation of the radiosensitizing effects of the selective COX-2 inhibitor celecoxib in secondary bone tumors of a non-small cell lung carcinoma in vivo.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| s00066-010-2116-3.pdf | text | Adobe PDF | 1.19 MB | publisher | published |