The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

BORIS DOI
Publisher DOI
PubMed ID
33972964
Description
pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
Date of Publication
2021-05-05
Publication Type
Article
Subject(s)
500 - Science::570 - Life sciences; biology
500 - Science::540 - Chemistry
Language(s)
en
Contributor(s)
Köhler, Thilo
Additional Credits
Departement für Chemie, Biochemie und Pharmazie (DCBP)
Series
Chemical communications
Publisher
Royal Society of Chemistry
ISSN
1359-7345
Access(Rights)
open.access
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