Mesenchymal Stem Cell-Derived Exosomes as New Remedy for the Treatment of Neurocognitive Disorders
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BORIS DOI
Publisher DOI
PubMed ID
33535376
Description
Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.
Date of Publication
2021
Publication Type
Article
Subject(s)
Language(s)
en
Contributor(s)
Harrell, Carl Randall | |
Volarevic, Ana | |
Volarevic, Vladislav |
Additional Credits
Series
International journal of molecular sciences
Publisher
MDPI
ISSN
1422-0067
Access(Rights)
open.access