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  3. Birth characteristics and childhood leukemia in Switzerland: a register-based case-control study.
 

Birth characteristics and childhood leukemia in Switzerland: a register-based case-control study.

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BORIS DOI
10.48350/156077
Date of Publication
July 2021
Publication Type
Article
Division/Institute

Institut für Sozial- ...

Author
Lupatsch, Judith Eva
Institut für Sozial- und Präventivmedizin (ISPM)
Kreis, Christianorcid-logo
Institut für Sozial- und Präventivmedizin (ISPM)
Konstantinoudis, Garyfallosorcid-logo
Institut für Sozial- und Präventivmedizin (ISPM)
Ansari, Marc
Kühni, Claudia
Institut für Sozial- und Präventivmedizin (ISPM)
Spycher, Benorcid-logo
Institut für Sozial- und Präventivmedizin (ISPM)
Subject(s)

600 - Technology::610...

300 - Social sciences...

Series
CCC. Cancer causes & control
ISSN or ISBN (if monograph)
0957-5243
Publisher
Springer
Language
English
Publisher DOI
10.1007/s10552-021-01423-3
PubMed ID
33877514
Uncontrolled Keywords

Birth weight Epidemio...

Description
PURPOSE

Initial genetic alterations in the development of childhood leukemia occur in utero or before conception; both genetic and environmental factors are suspected to play a role. We aimed to investigate the associations between childhood leukemia and perinatal characteristics including birth order, birth interval to older siblings, parental age, birth weight, and multiple birth.

METHODS

We identified cases diagnosed between 1981 and 2015 and born in Switzerland between 1969 and 2015 from the Swiss Childhood Cancer Registry and randomly sampled five controls per case from national birth records matched on date of birth, sex, and municipality of residence at birth. We used conditional logistic regression to investigate associations between perinatal characteristics and leukemia at ages 0-15 and 0-4 years, and the subtypes acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

RESULTS

The study included 1,403 cases of leukemia. We observed increased risks associated with high birth weight (adjusted OR 1.37, 95% CI 1.12-1.69) and multiple birth (1.89, 1.24-2.86). These associations were similar for ALL and stronger for leukemia at ages 0-4 years. For AML, we observed an increased risk for higher birth order (3.08, 0.43-22.03 for fourth or later born children). We found no associations with other perinatal characteristics.

CONCLUSION

This register-based case-control study adds to the existing evidence of a positive association between high birth weight and risk of childhood leukemia. Furthermore, it suggests children from multiple births are at an increased risk of leukemia.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/56778
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Lupatsch_CancerCausesControl_2021.pdftextAdobe PDF684.44 KBAttribution (CC BY 4.0)publishedOpen
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