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  3. Meta-analysis as a system of springs.
 

Meta-analysis as a system of springs.

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BORIS DOI
10.7892/boris.149999
Publisher DOI
10.1002/jrsm.1470
PubMed ID
33264498
Description
Meta-analysis results are usually presented in forest plots, which show the individual study results and the summary effect along with their confidence intervals. In this paper, we propose a system of linear springs as a mechanical analogue of metaanalysis that enables visualisation and enhances intuition. The length of a spring corresponds to a study treatment effect and the stiffness of the spring corresponds to its inverse variance. To synthesise study springs we use two main operations: connection in parallel and connection in series. We show the equivalence between meta-analysis and linear springs for fixed effect and random effects pairwise metaanalysis and we also derive indirect treatment effects. We use examples to illustrate the different meta-analytical schemes using the corresponding system of springs. The proposed visualization tool can serve as an educational plot, especially useful for researchers with no statistical background. The analogy between meta-analysis and springs facilitates intuition for notions such as heterogeneity and the differences between fixed and random effects meta-analysis. This article is protected by copyright. All rights reserved.
Date of Publication
2021-01
Publication Type
Article
Subject(s)
600 - Technology::610 - Medicine & health
300 - Social sciences, sociology & anthropology::360 - Social problems & social services
Keyword(s)
evidence synthesis mechanical analogue visualization
Language(s)
en
Contributor(s)
Papakonstantinou, Theodorosorcid-logo
Institut für Sozial- und Präventivmedizin (ISPM)
Nikolakopoulou, Adriani
Institut für Sozial- und Präventivmedizin (ISPM)
Egger, Matthiasorcid-logo
Institut für Sozial- und Präventivmedizin (ISPM)
Salanti, Georgiaorcid-logo
Institut für Sozial- und Präventivmedizin (ISPM)
Additional Credits
Institut für Sozial- und Präventivmedizin (ISPM)
Series
Research Synthesis Methods
Publisher
Wiley
ISSN
1759-2879
Access(Rights)
open.access
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