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  3. Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases.
 

Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases.

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BORIS DOI
10.48620/85221
Date of Publication
January 15, 2025
Publication Type
Article
Division/Institute

Clinic of Cardiology

Author
Waschke, Jens
Amagai, Masayuki
Becker, Christoph
Delmar, Mario
Duru, Firat
Garrod, David R
Gerull, Brenda
Green, Kathleen J
Hertl, Michael
Kowalczyk, Andrew P
Niessen, Carien M
Nusrat, Asma
Schinner, Camilla
Clinic of Cardiology
Department for BioMedical Research (DBMR)
Schlegel, Nicolas
Sivasankar, Sanjeevi
Vielmuth, Franziska
Spindler, Volker
Subject(s)

600 - Technology::610...

Series
Journal of Cell Science
ISSN or ISBN (if monograph)
1477-9137
0021-9533
Publisher
The Company of Biologists
Language
English
Publisher DOI
10.1242/jcs.263796
PubMed ID
39838950
Description
Desmosomes are adhesive cell contacts abundant in tissues exposed to mechanical strain, such as the stratified and simple epithelia of the epidermis and mucous membranes, as well as the myocardium. Besides their role in mechanical cell cohesion, desmosomes also modulate pathways important for tissue differentiation, wound healing and immune responses. Dysfunctional desmosomes, resulting from pathogenic variants in genes encoding desmosomal components, autoantibodies targeting desmosomal adhesion molecules or inflammation, cause the life-threatening diseases arrhythmogenic cardiomyopathy and pemphigus and contribute to the pathogenesis of inflammatory bowel diseases. The Alpine Desmosome Disease Meeting 2024 (ADDM 2024), held in Grainau, Germany in October 2024, connected international researchers from basic sciences with clinical experts from dermatology, cardiology, gastroenterology and surgery. The participants discussed recent advances, identified hot topics in desmosome biology and disease and provided new concepts for pathogenesis and treatment approaches.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/203485
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jcs263796.pdftextAdobe PDF575.01 KBpublished
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