Prevalence of Mycoplasma genitalium in different population groups: systematic review and meta-analysis.
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BORIS DOI
Date of Publication
June 2018
Publication Type
Article
Division/Institute
Author
Baumann, Lukas | |
Cina, Manuel | |
Lohrer, Gian-Reto | |
Ali, Hammad |
Series
Sexually transmitted infections
ISSN or ISBN (if monograph)
1368-4973
Publisher
BMJ Publishing Group
Language
English
Publisher DOI
PubMed ID
29440466
Uncontrolled Keywords
Description
BACKGROUND
is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence ofin the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples, METHODS: We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. We included studies with 500 participants or more. Two reviewers independently screened and selected studies and extracted data. We examined forest plots and conducted random-effects meta-analysis to estimate prevalence, if appropriate. Between-study heterogeneity was examined using the Istatistic and meta-regression.
RESULTS
Of 3316 screened records, 63 were included. In randomly selected samples from the general population, the summary prevalence was 1.3% (95% CI 1.0% to 1.8%, I41.5%, three studies, 9091 people) in countries with higher levels of development and 3.9% (95% CI 2.2 to 6.7, I89.2%, three studies, 3809 people) in countries with lower levels. Prevalence was similar in women and men (P=0.47). In clinic based samples, prevalence estimates were higher, except in asymptomatic patients (0.8%, 95% CI 0.4 to 1.4, I0.0%, three studies, 2889 people). Summary prevalence estimates were, in the following groups: pregnant women 0.9% (95% CI 0.6% to 1.4%, I0%, four studies, 3472 people), MSM in the community 3.2% (95% CI 2.1 to 5.1, I78.3%, five studies, 3012 people) and female CSWs in the community 15.9% (95% CI 13.5 to 18.9, I79.9%, four studies, 4006 people).
DISCUSSION
This systematic review can inform testing guidelines for. The low estimated prevalence ofin the general population, pregnant women and asymptomatic attenders at clinics does not support expansion of testing to these groups.
REGISTRATION NUMBERS
PROSPERO: CRD42015020420.
is a common cause of non-gonococcal non-chlamydial urethritis and cervicitis. Testing of asymptomatic populations has been proposed, but prevalence in asymptomatic populations is not well established. We aimed to estimate the prevalence ofin the general population, pregnant women, men who have sex with men (MSM), commercial sex workers (CSWs) and clinic-based samples, METHODS: We searched Embase, Medline, IndMED, African Index Medicus and LILACS from 1 January 1991 to 12 July 2016 without language restrictions. We included studies with 500 participants or more. Two reviewers independently screened and selected studies and extracted data. We examined forest plots and conducted random-effects meta-analysis to estimate prevalence, if appropriate. Between-study heterogeneity was examined using the Istatistic and meta-regression.
RESULTS
Of 3316 screened records, 63 were included. In randomly selected samples from the general population, the summary prevalence was 1.3% (95% CI 1.0% to 1.8%, I41.5%, three studies, 9091 people) in countries with higher levels of development and 3.9% (95% CI 2.2 to 6.7, I89.2%, three studies, 3809 people) in countries with lower levels. Prevalence was similar in women and men (P=0.47). In clinic based samples, prevalence estimates were higher, except in asymptomatic patients (0.8%, 95% CI 0.4 to 1.4, I0.0%, three studies, 2889 people). Summary prevalence estimates were, in the following groups: pregnant women 0.9% (95% CI 0.6% to 1.4%, I0%, four studies, 3472 people), MSM in the community 3.2% (95% CI 2.1 to 5.1, I78.3%, five studies, 3012 people) and female CSWs in the community 15.9% (95% CI 13.5 to 18.9, I79.9%, four studies, 4006 people).
DISCUSSION
This systematic review can inform testing guidelines for. The low estimated prevalence ofin the general population, pregnant women and asymptomatic attenders at clinics does not support expansion of testing to these groups.
REGISTRATION NUMBERS
PROSPERO: CRD42015020420.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| Baumann SexTransmInfect 2018.pdf | text | Adobe PDF | 911.07 KB | Attribution (CC BY 4.0) | published |