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Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).

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BORIS DOI
10.7892/boris.93935
Date of Publication
March 2017
Publication Type
Article
Division/Institute

Universitätsklinik fü...

Author
Soria, Francesco
Shariat, Shahrokh F
Lerner, Seth P
Fritsche, Hans-Martin
Rink, Michael
Kassouf, Wassim
Spiess, Philippe E
Lotan, Yair
Ye, Dingwei
Fernández, Mario I
Kikuchi, Eiji
Chade, Daher C
Babjuk, Marko
Grollman, Arthur P
Thalmann, George
Universitätsklinik für Urologie
Subject(s)

600 - Technology::610...

Series
World journal of urology
ISSN or ISBN (if monograph)
0724-4983
Publisher
Springer
Language
English
Publisher DOI
10.1007/s00345-016-1928-x
PubMed ID
27604375
Uncontrolled Keywords

Diagnosis

Epidemiology

New technologies

Predictive tools

Prognosis

Risk factor

UTUC

Description
PURPOSE

Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment.

METHODS

Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance.

RESULTS

UTUC accounts for 5-10 % of all urothelial cancers, with an increasing incidence. UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics. Aristolochic acid plays an important role in UTUC pathogenesis in certain regions. It is further estimated that approximately 10 % of UTUC are part of the hereditary non-polyposis colorectal cancer spectrum disease. UTUC diagnosis remains mainly based on imaging and endoscopy, but development of new technologies is rapidly changing the diagnosis algorithm. To help the decision-making process regarding surgical treatment, extent of lymphadenectomy and selection of neoadjuvant systemic therapies, predictive tools based on preoperative patient and tumor characteristics have been developed.

CONCLUSIONS

Awareness regarding epidemiology, diagnosis, preoperative evaluation and prognostic assessment changes is essential to correctly diagnose and manage UTUC patients, thereby potentially improving their outcomes.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/148744
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