Publication:
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).

cris.virtualsource.author-orcid3515379f-ed0e-47d2-bb0e-0df6aa8ad3c8
datacite.rightsopen.access
dc.contributor.authorSoria, Francesco
dc.contributor.authorShariat, Shahrokh F
dc.contributor.authorLerner, Seth P
dc.contributor.authorFritsche, Hans-Martin
dc.contributor.authorRink, Michael
dc.contributor.authorKassouf, Wassim
dc.contributor.authorSpiess, Philippe E
dc.contributor.authorLotan, Yair
dc.contributor.authorYe, Dingwei
dc.contributor.authorFernández, Mario I
dc.contributor.authorKikuchi, Eiji
dc.contributor.authorChade, Daher C
dc.contributor.authorBabjuk, Marko
dc.contributor.authorGrollman, Arthur P
dc.contributor.authorThalmann, George
dc.date.accessioned2024-10-24T19:07:10Z
dc.date.available2024-10-24T19:07:10Z
dc.date.issued2017-03
dc.description.abstractPURPOSE Upper-tract urothelial carcinoma (UTUC) is a relatively uncommon disease with limited available evidence on specific topics. The purpose of this article was to review the previous literature to summarize the current knowledge about UTUC epidemiology, diagnosis, preoperative evaluation and prognostic assessment. METHODS Using MEDLINE, a non-systematic review was performed including articles between January 2000 and February 2016. English language original articles, reviews and editorials were selected based on their clinical relevance. RESULTS UTUC accounts for 5-10 % of all urothelial cancers, with an increasing incidence. UTUC and bladder cancer share some common risk factors, even if they are two different entities regarding practical, biological and clinical characteristics. Aristolochic acid plays an important role in UTUC pathogenesis in certain regions. It is further estimated that approximately 10 % of UTUC are part of the hereditary non-polyposis colorectal cancer spectrum disease. UTUC diagnosis remains mainly based on imaging and endoscopy, but development of new technologies is rapidly changing the diagnosis algorithm. To help the decision-making process regarding surgical treatment, extent of lymphadenectomy and selection of neoadjuvant systemic therapies, predictive tools based on preoperative patient and tumor characteristics have been developed. CONCLUSIONS Awareness regarding epidemiology, diagnosis, preoperative evaluation and prognostic assessment changes is essential to correctly diagnose and manage UTUC patients, thereby potentially improving their outcomes.
dc.description.numberOfPages9
dc.description.sponsorshipUniversitätsklinik für Urologie
dc.identifier.doi10.7892/boris.93935
dc.identifier.pmid27604375
dc.identifier.publisherDOI10.1007/s00345-016-1928-x
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/148744
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofWorld journal of urology
dc.relation.issn0724-4983
dc.relation.organizationDCD5A442C238E17DE0405C82790C4DE2
dc.subjectDiagnosis
dc.subjectEpidemiology
dc.subjectNew technologies
dc.subjectPredictive tools
dc.subjectPrognosis
dc.subjectRisk factor
dc.subjectUTUC
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleEpidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage387
oaire.citation.issue3
oaire.citation.startPage379
oaire.citation.volume35
oairecerif.author.affiliationUniversitätsklinik für Urologie
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unibe.description.ispublishedpub
unibe.eprints.legacyId93935
unibe.journal.abbrevTitleWORLD J UROL
unibe.refereedtrue
unibe.subtype.articlejournal

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