Transcriptional regulation of tenascin genes
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BORIS DOI
Date of Publication
2015
Publication Type
Article
Division/Institute
Author
Chiovaro, Francesca | |
Chiquet-Ehrismann, Ruth |
Subject(s)
Series
Cell adhesion & migration
ISSN or ISBN (if monograph)
1933-6918
Publisher
Landes Bioscience
Language
English
Publisher DOI
PubMed ID
25793574
Uncontrolled Keywords
Description
Extracellular matrix proteins of the tenascin family resemble each other in their domain structure, and also share functions in modulating cell adhesion and cellular responses to growth factors. Despite these common features, the 4 vertebrate tenascins exhibit vastly different expression patterns. Tenascin-R is specific to the central nervous system. Tenascin-C is an "oncofetal" protein controlled by many stimuli (growth factors, cytokines, mechanical stress), but with restricted occurrence in space and time. In contrast, tenascin-X is a constituitive component of connective tissues, and its level is barely affected by external factors. Finally, the expression of tenascin-W is similar to that of tenascin-C but even more limited. In accordance with their highly regulated expression, the promoters of the tenascin-C and -W genes contain TATA boxes, whereas those of the other 2 tenascins do not. This article summarizes what is currently known about the complex transcriptional regulation of the 4 tenascin genes in development and disease.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| Transcriptional regulation of tenascin.pdf | text | Adobe PDF | 414.59 KB | published |