Fetal programming and epigenetic mechanisms in arterial hypertension.
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BORIS DOI
Date of Publication
July 2015
Publication Type
Article
Division/Institute
Series
Current opinion in cardiology
ISSN or ISBN (if monograph)
0268-4705
Publisher
Lippincott Williams & Wilkins
Language
English
Publisher DOI
PubMed ID
26049388
Description
PURPOSE OF REVIEW
To provide an overview of available evidence of the potential role of epigenetics in the pathogenesis of hypertension and vascular dysfunction.
RECENT FINDINGS
Arterial hypertension is a highly heritable condition. Surprisingly, however, genetic variants only explain a tiny fraction of the phenotypic variation and the term 'missing heritability' has been coined to describe this phenomenon. Recent evidence suggests that phenotypic alteration that is unrelated to changes in DNA sequence (thereby escaping detection by classic genetic methodology) offers a potential explanation. Here, we present some basic information on epigenetics and review recent work consistent with the hypothesis of epigenetically induced arterial hypertension.
SUMMARY
New technologies that enable the rigorous assessment of epigenetic changes and their phenotypic consequences may provide the basis for explaining the missing heritability of arterial hypertension and offer new possibilities for treatment and/or prevention.
To provide an overview of available evidence of the potential role of epigenetics in the pathogenesis of hypertension and vascular dysfunction.
RECENT FINDINGS
Arterial hypertension is a highly heritable condition. Surprisingly, however, genetic variants only explain a tiny fraction of the phenotypic variation and the term 'missing heritability' has been coined to describe this phenomenon. Recent evidence suggests that phenotypic alteration that is unrelated to changes in DNA sequence (thereby escaping detection by classic genetic methodology) offers a potential explanation. Here, we present some basic information on epigenetics and review recent work consistent with the hypothesis of epigenetically induced arterial hypertension.
SUMMARY
New technologies that enable the rigorous assessment of epigenetic changes and their phenotypic consequences may provide the basis for explaining the missing heritability of arterial hypertension and offer new possibilities for treatment and/or prevention.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| 00001573-201507000-00015.pdf | text | Adobe PDF | 349.09 KB | publisher | published |