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Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia

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cris.virtual.author-orcid0000-0002-9005-0655
cris.virtualsource.author-orcidca7b7138-fe4f-4995-8bf0-7a7da3cd819f
cris.virtualsource.author-orcidd9b15728-d399-4747-a56b-aab7bb3b5dfa
dc.contributor.authorGantenbein, Benjamin
dc.contributor.authorCalandriello, Elena
dc.contributor.authorWuertz-Kozak, Karin
dc.contributor.authorBenneker, Lorin Michael
dc.contributor.authorKeel, Marius JB
dc.contributor.authorChan, Samantha CW
dc.date.accessioned2024-10-23T17:14:38Z
dc.date.available2024-10-23T17:14:38Z
dc.date.issued2014
dc.description.abstractNotochordal cells (NC) remain in the focus of research for regenerative therapy for the degenerated intervertebral disc (IVD) due to their progenitor status. Recent findings suggested their regenerative action on more mature disc cells, presumably by the secretion of specific factors, which has been described as notochordal cell conditioned medium (NCCM). The aim of this study was to determine NC culture conditions (2D/3D, fetal calf serum, oxygen level) that lead to significant IVD cell activation in an indirect co-culture system under normoxia and hypoxia (2% oxygen).
dc.description.sponsorshipInstitut für chirurgische Technologien und Biomechanik (ISTB)
dc.description.sponsorshipUniversitätsklinik für Orthopädische Chirurgie und Traumatologie
dc.identifier.doi10.7892/boris.61154
dc.identifier.pmid25496082
dc.identifier.publisherDOI10.1186/1471-2474-15-422
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/127961
dc.language.isoen
dc.publisherBioMed Central
dc.relation.ispartofBMC musculoskeletal disorders
dc.relation.issn1471-2474
dc.relation.organizationDCD5A442BADEE17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BCD5E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.subject.ddc600 - Technology::620 - Engineering
dc.titleActivation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
dspace.file.typetext
oaire.citation.issue422
oaire.citation.startPage422
oaire.citation.volume15
oairecerif.author.affiliationInstitut für chirurgische Technologien und Biomechanik (ISTB)
oairecerif.author.affiliationUniversitätsklinik für Orthopädische Chirurgie und Traumatologie
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unibe.description.ispublishedpub
unibe.eprints.legacyId61154
unibe.journal.abbrevTitleBMC MUSCULOSKEL DIS
unibe.refereedTRUE
unibe.subtype.articlejournal

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