Evaluating the Minimal Clinically Important Difference of EQ-5D-3L in Patients with Degenerative Lumbar Spinal Stenosis: A Swiss Prospective Multi-Center Cohort Study.
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BORIS DOI
Date of Publication
September 15, 2020
Publication Type
Article
Division/Institute
Contributor
Burgstaller, Jakob M | |
Ulrich, Nils H | |
Pichierri, Giuseppe | |
Brunner, Florian | |
Farshad, Mazda | |
Porchet, François | |
Steurer, Johann | |
Gravestock, Isaac |
Subject(s)
Series
Spine
ISSN or ISBN (if monograph)
1528-1159
Publisher
Wolters Kluwer Health
Language
English
Publisher DOI
PubMed ID
32205700
Description
STUDY DESIGN
Analysis of a prospective, multicenter cohort study
OBJECTIVE
The aim of our study was to compare thresholds of published minimal clinically important differences (MCID) for the 3-level EuroQol-5D health survey (EQ-5D-3L) summary index (range -0.53 to 1.00) with our anchor-based estimate and evaluate how useful these thresholds are in determining treatment success in patients undergoing surgery for degenerative lumbar spinal stenosis (DLSS).
SUMMARY OF BACKGROUND DATA
MCID values for EQ-5D-3L are specific to the underlying disease and only three studies have been published for DLSS patients reporting different values.
METHODS
Patients of the multi-center Lumbar Stenosis Outcome Study (LSOS) with confirmed DLSS undergoing first-time decompression or fusion surgery with 12-month follow-up were enrolled in this study. To calculate MCID we used the Spinal Stenosis Measure (SSM) satisfaction subscale as anchor.
RESULTS
For this study, 364 patients met the inclusion criteria; of these, 196 were very satisfied, 72 moderately satisfied, 43 somewhat satisfied and 53 unsatisfied 12-month after surgery. The MCID calculation estimated for EQ-5D-3L a value of 0.19. Compared to published MCID values (ranging from 0.30 to 0.52), our estimation is less restrictive.
CONCLUSIONS
In patients with LSS undergoing surgery, we estimated an MCID value for EQ-5D-3L summary index of 0.19 with help of the average change anchor-based method, which we find to be the most suitable method for assessing patient change scores.
LEVEL OF EVIDENCE
3.
Analysis of a prospective, multicenter cohort study
OBJECTIVE
The aim of our study was to compare thresholds of published minimal clinically important differences (MCID) for the 3-level EuroQol-5D health survey (EQ-5D-3L) summary index (range -0.53 to 1.00) with our anchor-based estimate and evaluate how useful these thresholds are in determining treatment success in patients undergoing surgery for degenerative lumbar spinal stenosis (DLSS).
SUMMARY OF BACKGROUND DATA
MCID values for EQ-5D-3L are specific to the underlying disease and only three studies have been published for DLSS patients reporting different values.
METHODS
Patients of the multi-center Lumbar Stenosis Outcome Study (LSOS) with confirmed DLSS undergoing first-time decompression or fusion surgery with 12-month follow-up were enrolled in this study. To calculate MCID we used the Spinal Stenosis Measure (SSM) satisfaction subscale as anchor.
RESULTS
For this study, 364 patients met the inclusion criteria; of these, 196 were very satisfied, 72 moderately satisfied, 43 somewhat satisfied and 53 unsatisfied 12-month after surgery. The MCID calculation estimated for EQ-5D-3L a value of 0.19. Compared to published MCID values (ranging from 0.30 to 0.52), our estimation is less restrictive.
CONCLUSIONS
In patients with LSS undergoing surgery, we estimated an MCID value for EQ-5D-3L summary index of 0.19 with help of the average change anchor-based method, which we find to be the most suitable method for assessing patient change scores.
LEVEL OF EVIDENCE
3.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| Burgstaller, Spine 2020.pdf | Adobe PDF | 477.58 KB | publisher | accepted |