The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human
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BORIS DOI
Date of Publication
2010
Publication Type
Article
Division/Institute
Author
Jaunin, Fabienne | |
Begre, Nadja | |
Marcus, Katrin | |
Hashimoto, Takashi |
Subject(s)
Series
PLoS ONE
ISSN or ISBN (if monograph)
1932-6203
Publisher
Public Library of Science
Language
English
Publisher DOI
PubMed ID
20805888
Description
Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin families involved in maintenance of cell architecture and tissue cohesion. Nevertheless, the identity of an antigen of Mr 170,000 (p170), thought to be critical in PNP pathogenesis, has remained unknown.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| fetchObject.pdf | text | Adobe PDF | 654.61 KB | Attribution (CC BY 4.0) | published |