Publication: Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization.
cris.virtualsource.author-orcid | fb99e59d-56d8-4e1d-87a2-10152d09d1ca | |
cris.virtualsource.author-orcid | 3934a4dc-16e8-4037-a01a-cc7352d5327a | |
cris.virtualsource.author-orcid | 298a7be9-249d-49cb-b4e2-02e391f0fe05 | |
dc.contributor.author | Guex, A G | |
dc.contributor.author | Frobert, A | |
dc.contributor.author | Valentin, J | |
dc.contributor.author | Fortunato, G | |
dc.contributor.author | Hegemann, D | |
dc.contributor.author | Cook, S | |
dc.contributor.author | Carrel, Thierry | |
dc.contributor.author | Tevaearai, Hendrik | |
dc.contributor.author | Giraud, Marie-Noelle | |
dc.date.accessioned | 2024-10-23T17:32:25Z | |
dc.date.available | 2024-10-23T17:32:25Z | |
dc.date.issued | 2014-07 | |
dc.description.abstract | Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS). | |
dc.description.numberOfPages | 11 | |
dc.description.sponsorship | Universitätsklinik für Herz- und Gefässchirurgie | |
dc.identifier.doi | 10.7892/boris.63194 | |
dc.identifier.pmid | 24531014 | |
dc.identifier.publisherDOI | 10.1016/j.actbio.2014.01.006 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/129314 | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Acta biomaterialia | |
dc.relation.issn | 1742-7061 | |
dc.relation.organization | DCD5A442BADFE17DE0405C82790C4DE2 | |
dc.subject | Cardiac tissue engineering | |
dc.subject | Echocardiography | |
dc.subject | cell therapy | |
dc.subject | Electrospinning | |
dc.subject | In vivo functional evaluation | |
dc.subject | Plasma polymerization | |
dc.subject.ddc | 600 - Technology::610 - Medicine & health | |
dc.title | Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization. | |
dc.type | article | |
dspace.entity.type | Publication | |
dspace.file.type | text | |
oaire.citation.endPage | 3006 | |
oaire.citation.issue | 7 | |
oaire.citation.startPage | 2996 | |
oaire.citation.volume | 10 | |
oairecerif.author.affiliation | Universitätsklinik für Herz- und Gefässchirurgie | |
oairecerif.author.affiliation | Universitätsklinik für Herz- und Gefässchirurgie | |
oairecerif.author.affiliation | Universitätsklinik für Herz- und Gefässchirurgie | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.description.ispublished | pub | |
unibe.eprints.legacyId | 63194 | |
unibe.journal.abbrevTitle | ACTA BIOMATER | |
unibe.refereed | TRUE | |
unibe.subtype.article | journal |
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