Publication:
Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization.

cris.virtualsource.author-orcidfb99e59d-56d8-4e1d-87a2-10152d09d1ca
cris.virtualsource.author-orcid3934a4dc-16e8-4037-a01a-cc7352d5327a
cris.virtualsource.author-orcid298a7be9-249d-49cb-b4e2-02e391f0fe05
dc.contributor.authorGuex, A G
dc.contributor.authorFrobert, A
dc.contributor.authorValentin, J
dc.contributor.authorFortunato, G
dc.contributor.authorHegemann, D
dc.contributor.authorCook, S
dc.contributor.authorCarrel, Thierry
dc.contributor.authorTevaearai, Hendrik
dc.contributor.authorGiraud, Marie-Noelle
dc.date.accessioned2024-10-23T17:32:25Z
dc.date.available2024-10-23T17:32:25Z
dc.date.issued2014-07
dc.description.abstractCardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).
dc.description.numberOfPages11
dc.description.sponsorshipUniversitätsklinik für Herz- und Gefässchirurgie
dc.identifier.doi10.7892/boris.63194
dc.identifier.pmid24531014
dc.identifier.publisherDOI10.1016/j.actbio.2014.01.006
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/129314
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofActa biomaterialia
dc.relation.issn1742-7061
dc.relation.organizationDCD5A442BADFE17DE0405C82790C4DE2
dc.subjectCardiac tissue engineering
dc.subjectEchocardiography
dc.subjectcell therapy
dc.subjectElectrospinning
dc.subjectIn vivo functional evaluation
dc.subjectPlasma polymerization
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titlePlasma-functionalized electrospun matrix for biograft development and cardiac function stabilization.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage3006
oaire.citation.issue7
oaire.citation.startPage2996
oaire.citation.volume10
oairecerif.author.affiliationUniversitätsklinik für Herz- und Gefässchirurgie
oairecerif.author.affiliationUniversitätsklinik für Herz- und Gefässchirurgie
oairecerif.author.affiliationUniversitätsklinik für Herz- und Gefässchirurgie
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
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unibe.description.ispublishedpub
unibe.eprints.legacyId63194
unibe.journal.abbrevTitleACTA BIOMATER
unibe.refereedTRUE
unibe.subtype.articlejournal

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