Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization.
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BORIS DOI
Date of Publication
July 2014
Publication Type
Article
Division/Institute
Author
Guex, A G | |
Frobert, A | |
Valentin, J | |
Fortunato, G | |
Hegemann, D | |
Cook, S |
Subject(s)
Series
Acta biomaterialia
ISSN or ISBN (if monograph)
1742-7061
Publisher
Elsevier
Language
English
Publisher DOI
PubMed ID
24531014
Description
Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS).
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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1-s2.0-S1742706114000099-main.pdf | text | Adobe PDF | 2.1 MB | publisher | published |