Publication: Synthesis of pyrrolidine C-nucleosides via Heck reaction
| cris.virtual.author-orcid | 0000-0002-7996-7083 | |
| cris.virtualsource.author-orcid | 5a3c1532-b3c6-460c-8667-dc9093d5c9c6 | |
| datacite.rights | restricted | |
| dc.contributor.author | Häberli, A. | |
| dc.contributor.author | Leumann, Christian | |
| dc.date.accessioned | 2024-10-23T18:24:32Z | |
| dc.date.available | 2024-10-23T18:24:32Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | A novel method for the synthesis of pyrrolidine C-nucleosides has been developed. The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative 15 can easily be converted to the corresponding phosphoramidite building blocks for DNA synthesis | |
| dc.description.numberOfPages | 4 | |
| dc.description.sponsorship | Departement für Chemie und Biochemie (DCB) | |
| dc.identifier.doi | 10.7892/boris.68590 | |
| dc.identifier.publisherDOI | 10.1021/ol007029s | |
| dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/133084 | |
| dc.language.iso | en | |
| dc.publisher | American Chemical Society | |
| dc.relation.ispartof | Organic letters | |
| dc.relation.issn | 1523-7060 | |
| dc.relation.organization | DCD5A442C14DE17DE0405C82790C4DE2 | |
| dc.subject | BUILDING-BLOCKS C-nucleosides DNA phosphoramidite pyrrolidino-DNA synthesis | |
| dc.subject.ddc | 500 - Science::570 - Life sciences; biology | |
| dc.subject.ddc | 500 - Science::540 - Chemistry | |
| dc.title | Synthesis of pyrrolidine C-nucleosides via Heck reaction | |
| dc.type | article | |
| dspace.entity.type | Publication | |
| dspace.file.type | text | |
| oaire.citation.endPage | 492 | |
| oaire.citation.issue | 3 | |
| oaire.citation.startPage | 489 | |
| oaire.citation.volume | 3 | |
| oairecerif.author.affiliation | Departement für Chemie und Biochemie (DCB) | |
| unibe.contributor.role | creator | |
| unibe.contributor.role | creator | |
| unibe.description.ispublished | pub | |
| unibe.eprints.legacyId | 68590 | |
| unibe.journal.abbrevTitle | ORG LETT | |
| unibe.refereed | true | |
| unibe.subtype.article | journal |
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