Synthesis of pyrrolidine C-nucleosides via Heck reaction
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BORIS DOI
Date of Publication
2001
Publication Type
Article
Division/Institute
Author
Series
Organic letters
ISSN or ISBN (if monograph)
1523-7060
Publisher
American Chemical Society
Language
English
Publisher DOI
Uncontrolled Keywords
Description
A novel method for the synthesis of pyrrolidine C-nucleosides has been developed. The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative 15 can easily be converted to the corresponding phosphoramidite building blocks for DNA synthesis