Adams, Hieab H HHieab H HAdamsHibar, Derrek PDerrek PHibarChouraki, VincentVincentChourakiStein, Jason LJason LSteinNyquist, Paul APaul ANyquistRentería, Miguel EMiguel ERenteríaTrompet, StellaStellaTrompetArias-Vasquez, AlejandroAlejandroArias-VasquezSeshadri, SudhaSudhaSeshadriDesrivières, SylvaneSylvaneDesrivièresBeecham, Ashley HAshley HBeechamJahanshad, NedaNedaJahanshadWittfeld, KatharinaKatharinaWittfeldVan der Lee, Sven JSven JVan der LeeAbramovic, LucijaLucijaAbramovicAlhusaini, SaudSaudAlhusainiAmin, NajafNajafAminAndersson, MicaelMicaelAnderssonArfanakis, KonstantinosKonstantinosArfanakisAribisala, Benjamin SBenjamin SAribisalaArmstrong, Nicola JNicola JArmstrongAthanasiu, LaviniaLaviniaAthanasiuAxelsson, TomasTomasAxelssonBeiser, AlexaAlexaBeiserBernard, ManonManonBernardBis, Joshua CJoshua CBisBlanken, Laura M ELaura M EBlankenBlanton, Susan HSusan HBlantonBohlken, Marc MMarc MBohlkenBoks, Marco PMarco PBoksBralten, JanitaJanitaBraltenBrickman, Adam MAdam MBrickmanCarmichael, OwenOwenCarmichaelChakravarty, M MallarM MallarChakravartyChauhan, GaneshGaneshChauhanChen, QiangQiangChenChing, Christopher R KChristopher R KChingCuellar-Partida, GabrielGabrielCuellar-PartidaBraber, Anouk DenAnouk DenBraberDoan, Nhat TrungNhat TrungDoanEhrlich, StefanStefanEhrlichFilippi, IrinaIrinaFilippiGe, TianTianGeGiddaluru, SudheerSudheerGiddaluruGoldman, Aaron LAaron LGoldmanGottesman, Rebecca FRebecca FGottesmanGreven, Corina UCorina UGrevenGrimm, OliverOliverGrimmGriswold, Michael EMichael EGriswoldGuadalupe, TulioTulioGuadalupeHass, JohannaJohannaHassHaukvik, Unn KUnn KHaukvikHilal, SaimaSaimaHilalHofer, EdithEdithHoferHoehn, DavidDavidHoehnHolmes, Avram JAvram JHolmesHoogman, MartineMartineHoogmanJanowitz, DeborahDeborahJanowitzJia, TianyeTianyeJiaKasperaviciute, DaliaDaliaKasperaviciuteKim, SungeunSungeunKimKlein, MariekeMariekeKleinKraemer, BerndBerndKraemerLee, Phil HPhil HLeeLiao, JieminJieminLiaoLiewald, David C MDavid C MLiewaldLopez, Lorna MLorna MLopezLuciano, MichelleMichelleLucianoMacare, ChristineChristineMacareMarquand, AndreAndreMarquandMatarin, MarMarMatarinMather, Karen AKaren AMatherMattheisen, ManuelManuelMattheisenMazoyer, BernardBernardMazoyerMcKay, David RDavid RMcKayMcWhirter, RebekahRebekahMcWhirterMilaneschi, YuriYuriMilaneschiMirza-Schreiber, NazaninNazaninMirza-SchreiberMuetzel, Ryan LRyan LMuetzelManiega, Susana MuñozSusana MuñozManiegaNho, KwangsikKwangsikNhoNugent, Allison CAllison CNugentLoohuis, Loes M OldeLoes M OldeLoohuisOosterlaan, JaapJaapOosterlaanPapmeyer, MartinaMartinaPapmeyerPappa, IreneIrenePappaPirpamer, LukasLukasPirpamerPudas, SaraSaraPudasPütz, BennoBennoPützRajan, Kumar BKumar BRajanRamasamy, AdaikalavanAdaikalavanRamasamyRichards, Jennifer SJennifer SRichardsRisacher, Shannon LShannon LRisacherRoiz-Santiañez, RobertoRobertoRoiz-SantiañezRommelse, NandaNandaRommelseRose, Emma JEmma JRoseRoyle, Natalie ANatalie ARoyleRundek, TatjanaTatjanaRundekSämann, Philipp GPhilipp GSämannSatizabal, Claudia LClaudia LSatizabalSchmaal, LianneLianneSchmaalSchork, Andrew JAndrew JSchorkShen, LiLiShenShin, JeanJeanShinShumskaya, ElenaElenaShumskayaSmith, Albert VAlbert VSmithSprooten, EmmaEmmaSprootenStrike, Lachlan TLachlan TStrikeTeumer, AlexanderAlexanderTeumerThomson, RussellRussellThomsonTordesillas-Gutierrez, DianaDianaTordesillas-GutierrezToro, RobertoRobertoToroTrabzuni, DaniahDaniahTrabzuniVaidya, DhananjayDhananjayVaidyaVan der Grond, JeroenJeroenVan der GrondVan der Meer, DennisDennisVan der MeerVan Donkelaar, Marjolein M JMarjolein M JVan DonkelaarVan Eijk, Kristel RKristel RVan EijkVan Erp, Theo G MTheo G MVan ErpVan Rooij, DaanDaanVan RooijWalton, EstherEstherWaltonWestlye, Lars TLars TWestlyeWhelan, Christopher DChristopher DWhelanWindham, Beverly GBeverly GWindhamWinkler, Anderson MAnderson MWinklerWoldehawariat, GirmaGirmaWoldehawariatWolf, ChristianeChristianeWolfWolfers, ThomasThomasWolfersXu, BingBingXuYanek, Lisa RLisa RYanekYang, JingyunJingyunYangZijdenbos, AlexAlexZijdenbosZwiers, Marcel PMarcel PZwiersAgartz, IngridIngridAgartzAggarwal, Neelum TNeelum TAggarwalAlmasy, LauraLauraAlmasyAmes, DavidDavidAmesAmouyel, PhilippePhilippeAmouyelAndreassen, Ole AOle AAndreassenArepalli, SampathSampathArepalliAssareh, Amelia AAmelia AAssarehBarral, SandraSandraBarralBastin, Mark EMark EBastinBecker, Diane MDiane MBeckerBecker, James TJames TBeckerBennett, David ADavid ABennettBlangero, JohnJohnBlangerovan Bokhoven, HansHansvan BokhovenBoomsma, Dorret IDorret IBoomsmaBrodaty, HenryHenryBrodatyBrouwer, Rachel MRachel MBrouwerBrunner, Han GHan GBrunnerBuckner, Randy LRandy LBucknerBuitelaar, Jan KJan KBuitelaarBulayeva, Kazima BKazima BBulayevaCahn, WiepkeWiepkeCahnCalhoun, Vince DVince DCalhounCannon, Dara MDara MCannonCavalleri, Gianpiero LGianpiero LCavalleriChen, ChristopherChristopherChenCheng, Ching-YuChing-YuChengCichon, SvenSvenCichonCookson, Mark RMark RCooksonCorvin, AidenAidenCorvinCrespo-Facorro, BenedictoBenedictoCrespo-FacorroCurran, Joanne EJoanne ECurranCzisch, MichaelMichaelCzischDale, Anders MAnders MDaleDavies, Gareth EGareth EDaviesDe Geus, Eco J CEco J CDe GeusDe Jager, Philip LPhilip LDe Jagerde Zubicaray, Greig IGreig Ide ZubicarayDelanty, NormanNormanDelantyDepondt, ChantalChantalDepondtDeStefano, Anita LAnita LDeStefanoDillman, AllissaAllissaDillmanDjurovic, SrdjanSrdjanDjurovicDonohoe, GaryGaryDonohoeDrevets, Wayne CWayne CDrevetsDuggirala, RaviRaviDuggiralaDyer, Thomas DThomas DDyerErk, SusanneSusanneErkEspeseth, ThomasThomasEspesethEvans, Denis ADenis AEvansFedko, Iryna OIryna OFedkoFernández, GuillénGuillénFernándezFerrucci, LuigiLuigiFerrucciFisher, Simon ESimon EFisherFleischman, Debra ADebra AFleischmanFord, IanIanFordForoud, Tatiana MTatiana MForoudFox, Peter TPeter TFoxFrancks, ClydeClydeFrancksFukunaga, MasakiMasakiFukunagaGibbs, J RaphaelJ RaphaelGibbsGlahn, David CDavid CGlahnGollub, Randy LRandy LGollubGöring, Harald H HHarald H HGöringGrabe, Hans JHans JGrabeGreen, Robert CRobert CGreenGruber, OliverOliverGruberGudnason, VilmundurVilmundurGudnasonGuelfi, SebastianSebastianGuelfiHansell, Narelle KNarelle KHansellHardy, JohnJohnHardyHartman, Catharina ACatharina AHartmanHashimoto, RyotaRyotaHashimotoHegenscheid, KatrinKatrinHegenscheidHeinz, AndreasAndreasHeinzLe Hellard, StephanieStephanieLe HellardHernandez, Dena GDena GHernandezHeslenfeld, Dirk JDirk JHeslenfeldHo, Beng-ChoonBeng-ChoonHoHoekstra, Pieter JPieter JHoekstraHoffmann, WolfgangWolfgangHoffmannHofman, AlbertAlbertHofmanHolsboer, FlorianFlorianHolsboerHomuth, GeorgGeorgHomuthHosten, NorbertNorbertHostenHottenga, Jouke-JanJouke-JanHottengaPol, Hilleke E HulshoffHilleke E HulshoffPolIkeda, MasashiMasashiIkedaIkram, M KamranM KamranIkramJack, Clifford RClifford RJackJenkinson, MarkMarkJenkinsonJohnson, RobertRobertJohnsonJönsson, Erik GErik GJönssonJukema, J WouterJ WouterJukemaKahn, René SRené SKahnKanai, RyotaRyotaKanaiKloszewska, IwonaIwonaKloszewskaKnopman, David SDavid SKnopmanKochunov, PeterPeterKochunovKwok, John BJohn BKwokLawrie, Stephen MStephen MLawrieLemaître, HervéHervéLemaîtreLiu, XinminXinminLiuLongo, Dan LDan LLongoLongstreth, W TW TLongstrethLopez, Oscar LOscar LLopezLovestone, SimonSimonLovestoneMartinez, OliverOliverMartinezMartinot, Jean-LucJean-LucMartinotMattay, Venkata SVenkata SMattayMcDonald, ColmColmMcDonaldMcIntosh, Andrew MAndrew MMcIntoshMcMahon, Katie LKatie LMcMahonMcMahon, Francis JFrancis JMcMahonMecocci, PatriziaPatriziaMecocciMelle, IngridIngridMelleMeyer-Lindenberg, AndreasAndreasMeyer-LindenbergMohnke, SebastianSebastianMohnkeMontgomery, Grant WGrant WMontgomeryMorris, Derek WDerek WMorrisMosley, Thomas HThomas HMosleyMühleisen, Thomas WThomas WMühleisenMüller-Myhsok, BertramBertramMüller-MyhsokNalls, Michael AMichael ANallsNauck, MatthiasMatthiasNauckNichols, Thomas EThomas ENicholsNiessen, Wiro JWiro JNiessenNöthen, Markus MMarkus MNöthenNyberg, LarsLarsNybergOhi, KazutakaKazutakaOhiOlvera, Rene LRene LOlveraOphoff, Roel ARoel AOphoffPandolfo, MassimoMassimoPandolfoPaus, TomasTomasPausPausova, ZdenkaZdenkaPausovaPenninx, Brenda W J HBrenda W J HPenninxPike, G BruceG BrucePikePotkin, Steven GSteven GPotkinPsaty, Bruce MBruce MPsatyReppermund, SimoneSimoneReppermundRietschel, MarcellaMarcellaRietschelRoffman, Joshua LJoshua LRoffmanRomanczuk-Seiferth, NinaNinaRomanczuk-SeiferthRotter, Jerome IJerome IRotterRyten, MinaMinaRytenSacco, Ralph LRalph LSaccoSachdev, Perminder SPerminder SSachdevSaykin, Andrew JAndrew JSaykinSchmidt, ReinholdReinholdSchmidtSchofield, Peter RPeter RSchofieldSigurdsson, SigurdurSigurdurSigurdssonSimmons, AndyAndySimmonsSingleton, AndrewAndrewSingletonSisodiya, Sanjay MSanjay MSisodiyaSmith, ColinColinSmithSmoller, Jordan WJordan WSmollerSoininen, HilkkaHilkkaSoininenSrikanth, VelandaiVelandaiSrikanthSteen, Vidar MVidar MSteenStott, David JDavid JStottSussmann, Jessika EJessika ESussmannThalamuthu, AnbupalamAnbupalamThalamuthuTiemeier, HenningHenningTiemeierToga, Arthur WArthur WTogaTraynor, Bryan JBryan JTraynorTroncoso, JuanJuanTroncosoTurner, Jessica AJessica ATurnerTzourio, ChristopheChristopheTzourioUitterlinden, Andre GAndre GUitterlindenHernández, Maria C ValdésMaria C ValdésHernándezVan der Brug, MarcelMarcelVan der BrugVan der Lugt, AadAadVan der LugtVan der Wee, Nic J ANic J AVan der WeeVan Duijn, Cornelia MCornelia MVan DuijnVan Haren, Neeltje E MNeeltje E MVan HarenVan T Ent, DennisDennisVan T EntVan Tol, Marie-JoseMarie-JoseVan TolVardarajan, Badri NBadri NVardarajanVeltman, Dick JDick JVeltmanVernooij, Meike WMeike WVernooijVölzke, HenryHenryVölzkeWalter, HenrikHenrikWalterWardlaw, Joanna MJoanna MWardlawWassink, Thomas HThomas HWassinkWeale, Michael EMichael EWealeWeinberger, Daniel RDaniel RWeinbergerWeiner, Michael WMichael WWeinerWen, WeiWeiWenWestman, EricEricWestmanWhite, TonyaTonyaWhiteWong, Tien YTien YWongWright, Clinton BClinton BWrightZielke, H RonaldH RonaldZielkeZonderman, Alan BAlan BZondermanDeary, Ian JIan JDearyDeCarli, CharlesCharlesDeCarliSchmidt, HelenaHelenaSchmidtMartin, Nicholas GNicholas GMartinDe Craen, Anton J MAnton J MDe CraenWright, Margaret JMargaret JWrightLauner, Lenore JLenore JLaunerSchumann, GunterGunterSchumannFornage, MyriamMyriamFornageFranke, BarbaraBarbaraFrankeDebette, StéphanieStéphanieDebetteMedland, Sarah ESarah EMedlandIkram, M ArfanM ArfanIkramThompson, Paul MPaul MThompson2024-10-242024-10-242016-12https://boris-portal.unibe.ch/handle/20.500.12422/147457Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.921362769499110.1038/nn.4398