Tepekule, BurcuBurcuTepekuleJörimann, LisaLisaJörimannSchenkel, Corinne DCorinne DSchenkelOpitz, LennartLennartOpitzTschumi, JasminJasminTschumiWolfensberger, RebekkaRebekkaWolfensbergerNeumann, KathrinKathrinNeumannKusejko, KatharinaKatharinaKusejkoZeeb, MariusMariusZeebBoeck, LucasLucasBoeckKälin, MarisaMarisaKälinNotter, JuliaJuliaNotterFurrer, HansjakobHansjakobFurrer0000-0002-1375-3146Hoffmann, MatthiasMatthiasHoffmannHirsch, Hans HHans HHirschCalmy, AlexandraAlexandraCalmyCavassini, MatthiasMatthiasCavassiniLabhardt, Niklaus DNiklaus DLabhardtBernasconi, EnosEnosBernasconiOesch Nemeth, GabrielaGabrielaOesch NemethMetzner, Karin JKarin JMetznerBraun, Dominique LDominique LBraunGünthard, Huldrych FHuldrych FGünthardKouyos, Roger DRoger DKouyosDuffy, FergalFergalDuffyNemeth, JohannesJohannesNemeth2024-11-252024-11-252024-11-15https://boris-portal.unibe.ch/handle/20.500.12422/190683In people with HIV-1 (PWH), Mycobacterium tuberculosis (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population.enHealth sciencesMicrobiologyTranscriptomicsarticle10.48620/769533955541710.1016/j.isci.2024.111228