Bally, Lia ClaudiaLia ClaudiaBallyGubler, PhilippPhilippGublerThabit, HoodHoodThabitHartnell, SaraSaraHartnellRuan, YueYueRuanWilinska, Malgorzata EMalgorzata EWilinskaEvans, Mark LMark LEvansSemmo, MariamMariamSemmoVogt, BrunoBrunoVogtColl, Anthony PAnthony PCollStettler, ChristophChristophStettlerHovorka, RomanRomanHovorka2024-10-282024-10-282019-09https://boris-portal.unibe.ch/handle/20.500.12422/185674Inpatient diabetes management of those on hemodialysis poses a major challenge. In a post hoc analysis of a randomized controlled clinical trial, we compared the efficacy of fully automated closed-loop insulin delivery vs. usual care in patients undergoing hemodialysis while in hospital. Compared to control patients receiving conventional subcutaneous insulin therapy, those patients receiving closed-loop insulin delivery significantly increased the proportion of time when a continuous glucose monitor was in the target range of 5.6-10.0 mmol/l by 37.6 percent without increasing the risk of hypoglycemia. Thus, closed-loop insulin delivery offers a novel way to achieve effective and safe glucose control in this vulnerable patient population.enartificial pancreas closed-loop insulin delivery glucose control hemodialysis600 - Technology::610 - Medicine & healtharticle10.7892/boris.1383563113345710.1016/j.kint.2019.03.006