Murrell, Dedee FDedee FMurrellPeña, SandraSandraPeñaJoly, PascalPascalJolyMarinovic, BrankaBrankaMarinovicHashimoto, TakashiTakashiHashimotoDiaz, Luis ALuis ADiazSinha, Animesh AAnimesh ASinhaPayne, Aimee SAimee SPayneDaneshpazhooh, MaryamMaryamDaneshpazhoohEming, RüdigerRüdigerEmingJonkman, Marcel FMarcel FJonkmanMimouni, DanielDanielMimouniBorradori, LucaLucaBorradoriKim, Soo-ChanSoo-ChanKimYamagami, JunJunYamagamiLehman, Julia SJulia SLehmanSaleh, Marwah AdlyMarwah AdlySalehCulton, Donna ADonna ACultonCzernik, AnnetteAnnetteCzernikZone, John JJohn JZoneFivenson, DavidDavidFivensonUjiie, HideyukiHideyukiUjiieWozniak, KatarzynaKatarzynaWozniakAkman-Karakaş, AyşeAyşeAkman-KarakaşBernard, PhilippePhilippeBernardKorman, Neil JNeil JKormanCaux, FrédéricFrédéricCauxDrenovska, KossaraKossaraDrenovskaProst-Squarcioni, CatherineCatherineProst-SquarcioniVassileva, SnejinaSnejinaVassilevaFeldman, Ron JRon JFeldmanCardones, Adela RambiAdela RambiCardonesBauer, JohannJohannBauerIoannides, DimitriosDimitriosIoannidesJedlickova, HanaHanaJedlickovaPalisson, FrancisFrancisPalissonPatsatsi, AikateriniAikateriniPatsatsiUzun, SonerSonerUzunYayli, SavasSavasYayliZillikens, DetlefDetlefZillikensAmagai, MasayukiMasayukiAmagaiHertl, MichaelMichaelHertlSchmidt, EnnoEnnoSchmidtAoki, ValeriaValeriaAokiGrando, Sergei ASergei AGrandoShimizu, HiroshiHiroshiShimizuBaum, SharonSharonBaumCianchini, GuiseppeGuiseppeCianchiniFeliciani, ClaudioClaudioFelicianiIranzo, PilarPilarIranzoMascaró, Jose MJose MMascaróKowalewski, CezaryCezaryKowalewskiHall, RussellRussellHallGroves, RichardRichardGrovesHarman, Karen EKaren EHarmanMarinkovich, M PeterM PeterMarinkovichMaverakis, EmanualEmanualMaverakisWerth, Victoria PVictoria PWerth2024-10-072024-10-072020-03https://boris-portal.unibe.ch/handle/20.500.12422/61067BACKGROUND Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management, OBJECTIVE: We now present results from a subsequent Delphi consensus to broaden the generalizability of recommendations. METHODS A preliminary survey, based on the European Dermatology Forum (EDF) and the European Academy of Dermatology and Venereology (EADV) guidelines, was sent to a panel of international experts to determine the level of consensus. The results were discussed at the International Bullous Diseases Consensus Group in March 2016 during the annual American Academy of Dermatology (AAD) conference. A second survey was sent following the meeting to more experts to achieve greater international consensus. RESULTS The 39 experts participated in the first round of the Delphi-survey while 54 from 21 countries completed the second round. The number of statements in the survey was reduced from 175 topics in Delphi I to 24 topics in Delphi II based on Delphi results and meeting discussion. LIMITATIONS Each recommendation represents the majority opinion and therefore may not reflect all possible treatment options available. CONCLUSIONS We present here the recommendations resulting from this Delphi process. This international consensus includes intravenous CD20 inhibitors as a first line therapy option for moderate to severe pemphigus.enCD20 inhibitor consensus guidelines pemphigus foliaceus pemphigus vulgaris treatment600 - Technology::610 - Medicine & healtharticle10.7892/boris.1218792943876710.1016/j.jaad.2018.02.021