De Bruyne, BernardBernardDe BruynePijls, Nico H JNico H JPijlsKalesan, BinduBinduKalesanBarbato, EmanueleEmanueleBarbatoTonino, Pim A LPim A LToninoPiroth, ZsoltZsoltPirothJagic, NikolaNikolaJagicMöbius-Winkler, SvenSvenMöbius-WinklerRioufol, GillesGillesRioufolWitt, NilsNilsWittKala, PetrPetrKalaMacCarthy, PhilipPhilipMacCarthyEngström, ThomasThomasEngströmOldroyd, Keith GKeith GOldroydMavromatis, KretonKretonMavromatisManoharan, GaneshGaneshManoharanVerlee, PeterPeterVerleeFrobert, OleOleFrobertCurzen, NickNickCurzenJohnson, Jane BJane BJohnsonJüni, PeterPeterJüniFearon, William FWilliam FFearonFAME 2, Trial InvestigatorsTrial InvestigatorsFAME 22024-10-112024-10-112012https://boris-portal.unibe.ch/handle/20.500.12422/84050The preferred initial treatment for patients with stable coronary artery disease is the best available medical therapy. We hypothesized that in patients with functionally significant stenoses, as determined by measurement of fractional flow reserve (FFR), percutaneous coronary intervention (PCI) plus the best available medical therapy would be superior to the best available medical therapy alone.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.7892/boris.139812292463800030864910000510.1056/NEJMoa1205361