van Meel, Evelien REvelien Rvan MeelMensink-Bout, Sara MSara MMensink-Boutden Dekker, Herman THerman Tden DekkerAhluwalia, Tarunveer STarunveer SAhluwaliaAnnesi-Maesano, IsabellaIsabellaAnnesi-MaesanoArshad, Syed HasanSyed HasanArshadBaïz, NourNourBaïzBarros, HenriqueHenriqueBarrosvon Berg, AndreaAndreavon BergBisgaard, HansHansBisgaardBønnelykke, KlausKlausBønnelykkeCarlsson, Christian JChristian JCarlssonCasas, MaribelMaribelCasasChatzi, LedaLedaChatziChevrier, CecileCecileChevrierDalmeijer, GeertjeGeertjeDalmeijerDezateux, CarolCarolDezateuxDuchen, KarelKarelDuchenEggesbø, MereteMereteEggesbøvan der Ent, CornelisCornelisvan der EntFantini, MariaMariaFantiniFlexeder, ClaudiaClaudiaFlexederFrey, UrsUrsFreyForastiere, FransescoFransescoForastiereGehring, UlrikeUlrikeGehringGori, DavideDavideGoriGranell, RaquelRaquelGranellGriffiths, Lucy JLucy JGriffithsInskip, HazelHazelInskipJerzynska, JoannaJoannaJerzynskaKarvonen, Anne MAnne MKarvonenKeil, ThomasThomasKeilKelleher, CecilyCecilyKelleherKogevinas, ManolisManolisKogevinasKoppen, GudrunGudrunKoppenKühni, ClaudiaClaudiaKühniLambrechts, NathalieNathalieLambrechtsLau, SusanneSusanneLauLehmann, IrinaIrinaLehmannLudvigsson, JohnnyJohnnyLudvigssonMagnus, Maria ChristineMaria ChristineMagnusMélen, ErikErikMélenMehegan, JohnJohnMeheganMommers, MoniqueMoniqueMommersAndersen, Anne-Marie NyboAnne-Marie NyboAndersenNystad, WencheWencheNystadPedersen, Eva Sophie LundeEva Sophie LundePedersen0000-0003-0293-9954Pekkanen, JuhaJuhaPekkanenPeltola, VilleVillePeltolaPike, Katharine CKatharine CPikede Moira, Angela PinotAngela Pinotde MoiraPizzi, CostanzaCostanzaPizziPolanska, KingaKingaPolanskaPopovic, MajaMajaPopovicPorta, DanielaDanielaPortaRoberts, GrahamGrahamRobertsSantos, Ana CristinaAna CristinaSantosSchultz, Erica SErica SSchultzStandl, MarieMarieStandlSunyer, JordiJordiSunyerThijs, CarelCarelThijsToivonen, LauraLauraToivonenUphoff, EleonoraEleonoraUphoffUsemann, JakobJakobUsemannVafeidi, MarinaMarinaVafeidiWright, JohnJohnWrightde Jongste, Johan CJohan Cde JongsteJaddoe, Vincent W VVincent W VJaddoeDuijts, LiesbethLiesbethDuijts2024-10-092024-10-092022-10https://boris-portal.unibe.ch/handle/20.500.12422/70462BACKGROUND Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. OBJECTIVE To examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school-age. METHODS We used individual-participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75), and asthma at a median age of 7 (range 4 to 15) years. RESULTS Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75 (Z-score (95% CI): ranging from -0.09 (-0.14, -0.04) to -0.30 (-0.36, -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR (95%CI): ranging from 2.10 (1.98, 2.22) to 6.30 (5.64, 7.04)), and from 1.25 (1.18, 1.32) to 1.55 (1.47, 1.65)), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as proxy for early-life asthma. CONCLUSION Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower upper respiratory tract infections.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1696343548753710.1183/13993003.02395-2021