Ketelhut, Sascha IngemarSascha IngemarKetelhut0000-0002-6875-9625Ketelhut, Reinhard G.Reinhard G.KetelhutKircher, EvaEvaKircherRöglin, LisaLisaRöglinHottenrott, KunoKunoHottenrottMartin-Niedecken, Anna LisaAnna LisaMartin-NiedeckenKetelhut, KerstinKerstinKetelhut2024-10-312024-10-312022-01-27https://boris-portal.unibe.ch/handle/20.500.12422/188451Introduction: The present study assessed if an exercise session in an innovative exergame can modulate hemodynamic reactivity to a cold pressor test (CPT) to a similar extent as a typical moderate endurance training (ET). Furthermore, cardiorespiratory, and affective responses of an exergame session and an ET were compared. Methods: Twenty-seven healthy participants aged 25 ± 4 years (48% female; BMI 23.0 ± 2.1 kg/m2) participated in this cross-sectional study. All participants completed both an ET on a treadmill and training in the ExerCube (ECT). HR and oxygen consumption were recorded during both training sessions. Before and after both exercise sessions, the hemodynamic reactivity to a CPT was determined. Results: During ECT, HR, oxygen consumption, energy expenditure, and the metabolic equivalent of the task were significantly higher than those obtained during ET (p < 0.001). With regard to the CPT, the participants showed significantly lower responses in peripheral systolic (p = 0.004) and diastolic blood pressure (p = 0.009) as well as central systolic (p = 0.002) and diastolic BP (P = 0.01) after ECT compared to ET. The same was true for pulse wave velocity (p = 0.039). Conclusion: The ECT induced a significantly higher exercise stimulus compared to the ET. At the same time, it attenuated hemodynamic stress reactivity. The ECT presents a relevant training stimulus that modulates cardiovascular reactivity to stress, which has been proven as a predictor for the development of hypertension. Trial Registration: ISRCTN registry, ISRCTN43067716, 14 April 2020, Trial number: 38154.enexergamingcold pressor testhigh-intensity exercisegames for healthblood pressure reactivityhemodynamicsserious gamespulse wave velocity700 - Arts::790 - Sports, games & entertainmentarticle10.48350/1732843515562710.3389/fcvm.2022.798149