Heckmann, Christian M.Christian M.HeckmannParadisi, FrancescaFrancescaParadisi0000-0003-1704-06422024-10-052024-10-052021-12-01https://boris-portal.unibe.ch/handle/20.500.12422/54060The combination of biocatalysis and chemocatalysis can be more powerful than either technique alone. However, combining the two is challenging due to typically very different reaction conditions. Herein, chiral N-aryl amines, key features of many active pharmaceutical ingredients, are accessed in excellent enantioselectivity (typically>99.5 % ee) by combining transaminases with the Buchwald-Hartwig amination. By employing a bi-phasic buffer-toluene system as well as the ligand GPhos, the telescoped cascade proceeded with up to 89 % overall conversion in the presence of excess alanine. No coupling to alanine was observed.en500 - Science::540 - Chemistryarticle10.48350/1606353458578910.1002/chem.202103472