Vasilakaki, SofiaSofiaVasilakakiPastukhov, OleksandrOleksandrPastukhovMavromoustakos, ThomasThomasMavromoustakosHuwiler, AndreaAndreaHuwilerKokotos, GeorgeGeorgeKokotos2024-10-252024-10-252018-01-13https://boris-portal.unibe.ch/handle/20.500.12422/158499Peptide drug discovery may play a key role in the identification of novel medicinal agents. Here, we present the development of novel small peptides able to suppress the production of PGE₂ in mesangial cells. The new compounds were generated by structural alterations applied on GK115, a novel inhibitor of secreted phospholipase A₂, which has been previously shown to reduce PGE₂ synthesis in rat renal mesangial cells. Among the synthesized compounds, the tripeptide derivative 11 exhibited a nice dose-dependent suppression of PGE₂ production, similar to that observed for GK115.eninhibitors mesangial cells peptides prostaglandin E2 secreted phospholipase A2600 - Technology::610 - Medicine & healtharticle10.7892/boris.1114622934283510.3390/molecules23010158