Papageorgiou, MariaMariaPapageorgiouBiver, EmmanuelEmmanuelBiverMareschal, JulieJulieMareschalPhillips, Nicholas EdwardNicholas EdwardPhillipsHemmer, AlexandraAlexandraHemmerBiolley, EmmaEmmaBiolleySchwab, Nathalie ChristaNathalie ChristaSchwabManoogian, Emily N CEmily N CManoogianGonzalez Rodriguez, ElenaElenaGonzalez RodriguezAeberli, DanielDanielAeberliHans, DidierDidierHansPot, CarolineCarolinePotPanda, SatchidanandaSatchidanandaPandaRodondi, NicolasNicolasRodondiFerrari, Serge LSerge LFerrariCollet, Tinh-HaiTinh-HaiCollet2024-10-112024-10-112023-02https://boris-portal.unibe.ch/handle/20.500.12422/88104OBJECTIVE This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health. METHODS Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response. RESULTS In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes. CONCLUSIONS TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1737633623969510.1002/oby.23577