Wang, ZheZheWangEmmerich, AndrewAndrewEmmerichPillon, Nicolas JNicolas JPillonMoore, TimTimMooreHemerich, DaianeDaianeHemerichCornelis, Marilyn CMarilyn CCornelisMazzaferro, EugeniaEugeniaMazzaferroBroos, SiaciaSiaciaBroosAhluwalia, Tarunveer STarunveer SAhluwaliaBartz, Traci MTraci MBartzBentley, Amy RAmy RBentleyBielak, Lawrence FLawrence FBielakChong, MikeMikeChongChu, Audrey YAudrey YChuBerry, DianeDianeBerryDorajoo, RajkumarRajkumarDorajooDueker, Nicole DNicole DDuekerKasbohm, ElisaElisaKasbohmFeenstra, BjarkeBjarkeFeenstraFeitosa, Mary FMary FFeitosaGieger, ChristianChristianGiegerGraff, MariaelisaMariaelisaGraffHall, Leanne MLeanne MHallHaller, ToomasToomasHallerHartwig, Fernando PFernando PHartwigHillis, David ADavid AHillisHuikari, VilleVilleHuikariHeard-Costa, NancyNancyHeard-CostaHolzapfel, ChristinaChristinaHolzapfelJackson, Anne UAnne UJacksonJohansson, ÅsaÅsaJohanssonJørgensen, Anja MoltkeAnja MoltkeJørgensenKaakinen, Marika AMarika AKaakinenKarlsson, RobertRobertKarlssonKerr, Kathleen FKathleen FKerrKim, BoramBoramKimKoolhaas, Chantal MChantal MKoolhaasKutalik, ZoltanZoltanKutalikLagou, VasilikiVasilikiLagouLind, Penelope APenelope ALindLorentzon, MattiasMattiasLorentzonLyytikäinen, Leo-PekkaLeo-PekkaLyytikäinenMangino, MassimoMassimoManginoMetzendorf, ChristophChristophMetzendorfMonroe, Kristine RKristine RMonroePacolet, AlexanderAlexanderPacoletPérusse, LouisLouisPérussePool, ReneRenePoolRichmond, Rebecca CRebecca CRichmondRivera, Natalia VNatalia VRiveraRobiou-du-Pont, SebastienSebastienRobiou-du-PontSchraut, Katharina EKatharina ESchrautSchulz, Christina-AlexandraChristina-AlexandraSchulzStringham, Heather MHeather MStringhamTanaka, ToshikoToshikoTanakaTeumer, AlexanderAlexanderTeumerTurman, ConstanceConstanceTurmanvan der Most, Peter JPeter Jvan der MostVanmunster, MathiasMathiasVanmunstervan Rooij, Frank J AFrank J Avan Rooijvan Vliet-Ostaptchouk, Jana VJana Vvan Vliet-OstaptchoukZhang, XiaoshuaiXiaoshuaiZhangZhao, Jing-HuaJing-HuaZhaoZhao, WeiWeiZhaoBalkhiyarova, ZhannaZhannaBalkhiyarovaBalslev-Harder, Marie NMarie NBalslev-HarderBaumeister, Sebastian ESebastian EBaumeisterBeilby, JohnJohnBeilbyBlangero, JohnJohnBlangeroBoomsma, Dorret IDorret IBoomsmaBrage, SorenSorenBrageBraund, Peter SPeter SBraundBrody, Jennifer AJennifer ABrodyBruinenberg, MarcelMarcelBruinenbergEkelund, UlfUlfEkelundLiu, Ching-TiChing-TiLiuCole, John WJohn WColeCollins, Francis SFrancis SCollinsCupples, L AdrienneL AdrienneCupplesEsko, TõnuTõnuEskoEnroth, StefanStefanEnrothFaul, Jessica DJessica DFaulFernandez-Rhodes, LindsayLindsayFernandez-RhodesFohner, Alison EAlison EFohnerFranco Duran, Oscar HoracioOscar HoracioFranco DuranGalesloot, Tessel ETessel EGaleslootGordon, Scott DScott DGordonGrarup, NielsNielsGrarupHartman, Catharina ACatharina AHartmanHeiss, GerardoGerardoHeissHui, JennieJennieHuiIllig, ThomasThomasIlligJago, RussellRussellJagoJames, AlanAlanJamesJoshi, Peter KPeter KJoshiJung, TaeyeongTaeyeongJungKähönen, MikaMikaKähönenKilpeläinen, Tuomas OTuomas OKilpeläinenKoh, Woon-PuayWoon-PuayKohKolcic, IvanaIvanaKolcicKraft, Peter PPeter PKraftKuusisto, JohannaJohannaKuusistoLauner, Lenore JLenore JLaunerLi, AihuaAihuaLiLinneberg, AllanAllanLinnebergLuan, Jian'anJian'anLuanVidal, Pedro MarquesPedro MarquesVidalMedland, Sarah ESarah EMedlandMilaneschi, YuriYuriMilaneschiMoscati, ArdenArdenMoscatiMusk, BillBillMuskNelson, Christopher PChristopher PNelsonNolte, Ilja MIlja MNoltePedersen, Nancy LNancy LPedersenPeters, AnnetteAnnettePetersPeyser, Patricia APatricia APeyserPower, ChristineChristinePowerRaitakari, Olli TOlli TRaitakariReedik, MägiMägiReedikReiner, Alex PAlex PReinerRidker, Paul MPaul MRidkerRudan, IgorIgorRudanRyan, KathyKathyRyanSarzynski, Mark AMark ASarzynskiScott, Laura JLaura JScottScott, Robert ARobert AScottSidney, StephenStephenSidneySiggeirsdottir, KristinKristinSiggeirsdottirSmith, Albert VAlbert VSmithSmith, Jennifer AJennifer ASmithSonestedt, EmilyEmilySonestedtStrøm, MarinMarinStrømTai, E ShyongE ShyongTaiTeo, Koon KKoon KTeoThorand, BarbaraBarbaraThorandTönjes, AnkeAnkeTönjesTremblay, AngeloAngeloTremblayUitterlinden, Andre GAndre GUitterlindenVangipurapu, JagadishJagadishVangipurapuvan Schoor, NatasjaNatasjavan SchoorVölker, UweUweVölkerWillemsen, GonnekeGonnekeWillemsenWilliams, KayleenKayleenWilliamsWong, QuennaQuennaWongXu, HuichunHuichunXuYoung, Kristin LKristin LYoungYuan, Jian MinJian MinYuanZillikens, M CarolaM CarolaZillikensZonderman, Alan BAlan BZondermanAmeur, AdamAdamAmeurBandinelli, StefaniaStefaniaBandinelliBis, Joshua CJoshua CBisBoehnke, MichaelMichaelBoehnkeBouchard, ClaudeClaudeBouchardChasman, Daniel IDaniel IChasmanSmith, George DaveyGeorge DaveySmithde Geus, Eco J CEco J Cde GeusDeldicque, LouiseLouiseDeldicqueDörr, MarcusMarcusDörrEvans, Michele KMichele KEvansFerrucci, LuigiLuigiFerrucciFornage, MyriamMyriamFornageFox, CarolineCarolineFoxGarland, TheodoreTheodoreGarlandGudnason, VilmundurVilmundurGudnasonGyllensten, UlfUlfGyllenstenHansen, TorbenTorbenHansenHayward, CarolineCarolineHaywardHorta, Bernardo LBernardo LHortaHyppönen, ElinaElinaHyppönenJarvelin, Marjo-RiittaMarjo-RiittaJarvelinJohnson, W CraigW CraigJohnsonKardia, Sharon L RSharon L RKardiaKiemeney, Lambertus ALambertus AKiemeneyLaakso, MarkkuMarkkuLaaksoLangenberg, ClaudiaClaudiaLangenbergLehtimäki, TerhoTerhoLehtimäkiMarchand, Loic LeLoic LeMarchandMagnusson, Patrik K EPatrik K EMagnussonMartin, Nicholas GNicholas GMartinMelbye, MadsMadsMelbyeMetspalu, AndresAndresMetspaluMeyre, DavidDavidMeyreNorth, Kari EKari ENorthOhlsson, ClaesClaesOhlssonOldehinkel, Albertine JAlbertine JOldehinkelOrho-Melander, MarjuMarjuOrho-MelanderPare, GuillaumeGuillaumeParePark, TaesungTaesungParkPedersen, OlufOlufPedersenPenninx, Brenda W J HBrenda W J HPenninxPers, Tune HTune HPersPolasek, OzrenOzrenPolasekProkopenko, IngaIngaProkopenkoRotimi, Charles NCharles NRotimiSamani, Nilesh JNilesh JSamaniSim, XuelingXuelingSimSnieder, HaroldHaroldSniederSørensen, Thorkild I AThorkild I ASørensenSpector, Tim DTim DSpectorTimpson, Nicholas JNicholas JTimpsonvan Dam, Rob MRob Mvan Damvan der Velde, NathalieNathalievan der Veldevan Duijn, Cornelia MCornelia Mvan DuijnVollenweider, PeterPeterVollenweiderVölzke, HenryHenryVölzkeVoortman, TrudyTrudyVoortmanWaeber, GérardGérardWaeberWareham, Nicholas JNicholas JWarehamWeir, David RDavid RWeirWichmann, Heinz-ErichHeinz-ErichWichmannWilson, James FJames FWilsonHevener, Andrea LAndrea LHevenerKrook, AnnaAnnaKrookZierath, Juleen RJuleen RZierathThomis, Martine A IMartine A IThomisLoos, Ruth J FRuth J FLoosHoed, Marcel denMarcel denHoed2024-10-112024-10-112022-09https://boris-portal.unibe.ch/handle/20.500.12422/87329Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1727793607117210.1038/s41588-022-01165-1