Marchetti, OOMarchettiBille, JJBilleFluckiger, UUFluckigerEggimann, PPEggimannRuef, CCRuefGarbino, JJGarbinoCalandra, TTCalandraGlauser, MPMPGlauserTäuber, Martin G.Martin G.TäuberPittet, DDPittetFungal, Infection Network of SwitzerlandInfection Network of SwitzerlandFungal2024-10-132024-10-132004https://boris-portal.unibe.ch/handle/20.500.12422/99216Candida species are among the most common bloodstream pathogens in the United States, where the emergence of azole-resistant Candida glabrata and Candida krusei are major concerns. Recent comprehensive longitudinal data from Europe are lacking. We conducted a nationwide survey of candidemia during 1991-2000 in 17 university and university-affiliated hospitals representing 79% of all tertiary care hospital beds in Switzerland. The number of transplantations and bloodstream infections increased significantly (P<.001). A total of 1137 episodes of candidemia were observed: Candida species ranked seventh among etiologic agents (2.9% of all bloodstream isolates). The incidence of candidemia was stable over a 10-year period. C. albicans remained the predominant Candida species recovered (66%), followed by C. glabrata (15%). Candida tropicalis emerged (9%), the incidence of Candida parapsilosis decreased (1%), and recovery of C. krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred.enarticle10.7892/boris.257201472719900018820760000110.1086/380637