Baquet-Walscheid, KarolineKarolineBaquet-WalscheidMinden, KirstenKirstenMindenNiewerth, MartinaMartinaNiewerthDressler, FrankFrankDresslerFoeldvari, IvanIvanFoeldvariFoell, DirkDirkFoellHaas, Johannes-PeterJohannes-PeterHaasHorneff, GerdGerdHorneffHospach, AntonAntonHospachKallinich, TilmannTilmannKallinichKümmerle-Deschner, JasminJasminKümmerle-DeschnerMönkemöller, KirstenKirstenMönkemöllerTappeiner, ChristophChristophTappeiner0000-0001-6907-1112Windschall, DanielDanielWindschallKlotsche, JensJensKlotscheHeiligenhaus, ArndArndHeiligenhaus2025-04-162025-04-162025-03-20https://boris-portal.unibe.ch/handle/20.500.12422/207672Background Juvenile idiopathic arthritis-associated uveitis (JIAU) typically takes a chronic course, frequently leading to ocular complications and often requiring long-term treatment. The present study assesses the 5-years outcome of JIAU by analyzing data from a prospective study initiated in 2010.Methods Data from 75 patients with onset of uveitis after study enrollment, and with a documentation at 5-years follow-up (5yFU) were available for analysis of uveitis characteristics, frequency and predictors of "inactivity on medication " (defined as inactive uveitis for ≥ 6 months) and "inactivity off medication " (defined as inactive uveitis for ≥ 6 months off medication).Results At the 5yFU, visual acuity remained good in the majority of eyes (LogMAR < 0.1 in 65.5%; mean LogMAR 0.11 ± 0.31), ocular surgery was required in only 5% of patients, although complications occurred in 46.7% of patients until the 5yFU. Uveitis was inactive in 85.3% of patients, with 77.3% still receiving disease-modifying antirheumatic drugs (DMARDs). Until 5yFU, 82.7% of patients experienced ≥ one episode of "inactivity on medication " (30.7% once, 37.3% twice, 14.7% three or more times), and 17.3% ≥ one episode of "inactivity off medication ", respectively. Both "inactivity on medication " as well as "inactivity off medication " were associated with lower JIA disease activity (cJADAS10; ESR), and with an increased quality of life.Conclusions Despite intensified DMARD treatment, almost half of the children experience JIAU-related ocular complications after 5 years of disease; however, visual acuity mostly remains good. Uveitis inactivity can be achieved frequently, but is often limited in duration. Lower JIA activity appears to correlate with uveitis inactivity on and off medication.enBiological therapyJuvenile idiopathic arthritisPrognosisUveitis600 - Technology::610 - Medicine & healtharticle10.48620/873194011426210.1186/s13075-025-03531-w