Bachmann, NadineNadineBachmannvon Siebenthal, ChantalChantalvon SiebenthalVongrad, ValentinaValentinaVongradTurk, TejaTejaTurkNeumann, KathrinKathrinNeumannBeerenwinkel, NikoNikoBeerenwinkelBogojeska, JasminaJasminaBogojeskaFellay, JaquesJaquesFellayRoth, VolkerVolkerRothKok, Yik LimYik LimKokThorball, Christian WChristian WThorballBorghesi, AlessandroAlessandroBorghesiParbhoo, SonaliSonaliParbhooWieser, MarioMarioWieserBöni, JürgJürgBöniPerreau, MatthieuMatthieuPerreauKlimkait, ThomasThomasKlimkaitYerly, SabineSabineYerlyBattegay, ManuelManuelBattegayRauch, AndriAndriRauch0000-0001-5297-6062Hoffmann, MatthiasMatthiasHoffmannBernasconi, EnosEnosBernasconiCavassini, MatthiasMatthiasCavassiniKouyos, Roger DRoger DKouyosGünthard, Huldrych FHuldrych FGünthardMetzner, Karin JKarin JMetzner2024-10-282024-10-282019-07-19https://boris-portal.unibe.ch/handle/20.500.12422/184095The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.1362193132476210.1038/s41467-019-10884-9