Müller, Annelies KathrinAnnelies KathrinMüllerKleynhans, JackieJackieKleynhansde Gouveia, LindaLindade GouveiaMeiring, SusanSusanMeiringCohen, CherylCherylCohenHathaway, Lucy JaneLucy JaneHathaway0000-0002-5361-5397von Gottberg, AnneAnnevon Gottberg2024-10-092024-10-092022-01https://boris-portal.unibe.ch/handle/20.500.12422/66643The Streptococcus pneumoniae polysaccharide capsule plays a role in disease severity. We assessed the association of serotype with case-fatality ratio (CFR) in invasive pneumococcal disease (IPD) and meningitis in South Africa, 2012-2018 (vaccine era), using multivariable logistic regression by manual backward elimination. The most common serotypes causing IPD were 8 and 19A. In patients <15 years of age, serotypes associated with increased CFR in IPD, compared with serotype 8 and controlling for confounding factors, were 11A, 13, 19F, 15A, and 6A. None of these serotypes were associated with increased CFR in meningitis. Among IPD patients >15 years of age, serotype 15B/C was associated with increased CFR. Among meningitis patients of all ages, serotype 1 was associated with increased CFR. PCV13 serotypes 1, 3, 6A, 19A, and 19F should be monitored, and serotypes 8, 12F, 15A, and 15B/C should be considered for inclusion in vaccines to reduce deaths caused by S. pneumoniae.enSouth AfricaStreptococcusStreptococcus pneumoniaeSwitzerlandbacteriacase-fatality ratiomeningitis/encephalitismortalitypolysaccharide capsuleserotypestreptococci.500 - Science::570 - Life sciences; biology600 - Technology::610 - Medicine & healtharticle10.48350/1643513493244810.3201/eid2801.210956