Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Schomaker, MichaelMichaelSchomakerEgger, MatthiasMatthiasEgger0000-0001-7462-5132Maskew, MhairiMhairiMaskewGarone, DanielaDanielaGaroneProzesky, HansHansProzeskyHoffmann, Christopher J.Christopher J.HoffmannBoulle, AndrewAndrewBoulleFenner, LukasLukasFenner0000-0003-3309-48352024-10-142024-10-142013-05-01https://boris-portal.unibe.ch/handle/20.500.12422/112950We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/µL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesImmune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africaarticle10.7892/boris.408542336451310.1097/QAI.0b013e318288b39d