Shalaeva, EvgeniyaEvgeniyaShalaevaBano, ArjolaArjolaBanoKasimov, UlugbekUlugbekKasimovJanabaev, BakhtiyorBakhtiyorJanabaevBaumgartner, IrisIrisBaumgartnerLaimer, MarkusMarkusLaimer0000-0002-7622-0822Saner, Hugo ErnstHugo ErnstSaner2024-10-112024-10-112022-10https://boris-portal.unibe.ch/handle/20.500.12422/88050METHODS This is a single-center prospective cohort study including 199 consecutive patients with T2D, PAD (mean age 62.3 ± 7.2 years; 62.8% males), and preoperative CACS and CCTA undergoing PFA and followed-up over 1 year. RESULTS Over a period of 1 year follow-up, a total of 35 (17.6%) participants died. The area under ROC curve to predict mortality for the CACS was 0.835 (95% CI:0.769-0.900), for CCTA 0.858 (95% CI:0.788-0.927). After adjustment for confounders, compared to no-stenosis on CCTA (reference), the risk of all-cause mortality in non-obstructive coronary atery disease (CAD) increased (HR = 1.38, 95% CI [0.75-12.86], p = .284), 1-vessel obstructive CAD (HR = 8.13, 95% CI [0.87-75.88], p = .066), 2-vessels (HR = 10.94, 95% CI [1.03-115.8], p = .047), and 3-vessels (HR = 45.73, 95% CI [4.6-454.7], p = .001) respectively. Increasing levels of CACS tended to be associated with increased risk of all-cause mortality (HR = 1.002, 95% CI [1.0-1.003], p = .061). 61/95 patients with obstructive CAD underwent coronary revascularization. CONCLUSIONS Coronary artery calcium score and CCTA have a high predictive value for 1-year all-cause mortality in T2D patients undergoing minor amputations and may be considered for preoperative risk assessment allowing timely preventive interventions.enCoronary artery disease coronary artery calcium score coronary computed tomographic angiography partial foot amputation peripheral artery disease type 2 diabetes600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1737023622205310.1177/14791641221125190