Mosimann, BeatriceBeatriceMosimannAmylidi-Mohr, SofiaSofiaAmylidi-MohrHöland, KatrinKatrinHölandSurbek, DanielDanielSurbekRisch, LorenzLorenzRisch0000-0003-2692-6699Raio, LuigiLuigiRaio2024-10-252024-10-252017https://boris-portal.unibe.ch/handle/20.500.12422/158035OBJECTIVE The aims of this study were to test whether the performance of first-trimester placental growth factor (PlGF) in screening for preterm preeclampsia (PE) is gestational age dependent and to assess the value of serial first-trimester PlGF measurements in discriminating women at risk for PE. METHODS PlGF was measured in women with singleton pregnancies at their first antenatal visit at 8+0 to 10+6 and additionally at 11+0 to 14+0 weeks of gestation. The difference in absolute values of serial PlGF measurements was expressed as Δ-PlGF. Values were compared between pregnancies with normal outcome and those complicated by PE. RESULTS A total of 814 pregnancies were included, 18 (2.19%) developed PE that required delivery before 37 weeks of gestation. PlGF increases significantly from 8 to 14 weeks of gestation (ρ = 0.63; p < 0.0001) in normal pregnancies, but not so in preterm PE (ρ = 0.034; p = 0.893). PlGF discriminates between PE and uneventful pregnancies only after 10 weeks of gestation. Δ-PlGF was significantly lower in PE 5.3 (-1.1 to 9.3) pg/mL compared to uneventful pregnancies 17.3 (9.8-26.0) pg/mL (p = 0.0011). CONCLUSION The discriminatory accuracy of PlGF increases from 10 to 14 weeks of gestation, and serial PlGF measurements might be of particular interest in PE screening.enFirst trimester Placental growth factor Preeclampsia Prenatal screening600 - Technology::610 - Medicine & healtharticle10.7892/boris.1107832819999610.1159/000455946