Role of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial).

Branca, MattiaMattiaBrancaMarinosci, AnnalisaAnnalisaMarinosciSculier, DelphineDelphineSculierWandeler, GillesGillesWandelerYerly, SabineSabineYerlyStoeckle, MarcelMarcelStoeckleBernasconi, EnosEnosBernasconiBraun, Dominique L.Dominique L.BraunNeumann, KathrinKathrinNeumannVernazza, PietroPietroVernazzaCavassini, MatthiasMatthiasCavassiniBuzzi, MartaMartaBuzziDecosterd, Laurent A.Laurent A.DecosterdSchmid, PatrickPatrickSchmidLimacher, AndreasAndreasLimacher0000-0002-9094-9476Günthard, Huldrych F.Huldrych F.GünthardMetzner, Karin J.Karin J.MetznerCalmy, AlexandraAlexandraCalmy2024-10-112024-10-112022-05-19https://boris-portal.unibe.ch/handle/20.500.12422/85768HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simplified maintenance antiretroviral therapy in chronically HIV-1 infected patients. In the SIMPL’HIV trial, HIV-1 DNA was quantified in peripheral blood mononuclear cells obtained at baseline and week 48 to investigate changes over time and evidence of a predictive relationship to maintain HIV-1 RNA <20 copies/ml. Measurements were available for 175 patients, with no differences observed between treatment strategies. Findings showed that baseline HIV-1 DNA was lower in those with durable HIV-1 RNA <20 copies/ml compared with patients with incomplete viral suppression over 48 weeks.enHIV-1 reservoirdolutegravir+emtricitabinedual therapycARTHIV-1 RNA300 - Social sciences, sociology & anthropology::360 - Social problems & social services600 - Technology::610 - Medicine & healthRole of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial).article10.48350/17084010.3389/fviro.2022.855437