Molinero-Mourelle, PedroPedroMolinero-MourelleLimones, AlvaroAlvaroLimonesGüven, Mehmet EsadMehmet EsadGüvenFonseca, ManriqueManriqueFonsecaPeutzfeldt, AnneAnnePeutzfeldtYilmaz, BurakBurakYilmazÇakmak, GülceGülceÇakmak2025-04-302025-04-302024-02-21https://boris-portal.unibe.ch/handle/20.500.12422/210322Purpose To assess the manufacturing accuracy, intaglio surface adaptation, and survival of resin-based CAD/CAM definitive crowns created via additive manufacturing (AM) or subtractive manufacturing (SM).Materials And Methods A maxillary right first molar crown was digitally designed and manufactured using AM hybrid resin composite (VarseoSmile Crown Plus, Bego [AM-HRC]), AM glass filler-reinforced resin composite (Crowntec, Saremco Dental [AM-RC]), and SM polymer-infiltrated ceramic (Vita Enamic, VITA Zahnfabrik [SM-PICN]). Manufacturing accuracy (trueness and precision) was assessed by computing the root mean square (RMS) error (in μm; n = 15 per material). Intaglio surface adaptation was assessed by calculating the average gap distance (μm). Ten crowns from each group were cemented on fiberglass-reinforced epoxy resin dies and cyclically loaded to simulate 5 years of functional loading. One-way ANOVA, post hoc Bonferroni comparison tests, and Levene's test were used to analyze the data (α = .05).Results AM-RC had higher overall trueness than AM-HRC and SM-PICN (P ≤ .05), whereas the trueness of AM-RC on the external surface was similar to that of SM-PICN (P = .99) and higher than AM-HRC (P = .001). SM-PICN had lower precision than AM-RC and AM-HRC overall and at internal occlusal surfaces (P ≤ .05). Overall intaglio surface adaptation was similar between all groups (P = .531). However, for the axial intaglio surface, AM-RC and AM-HRC had higher adaptation than SM-PICN (P ≤ .05). All tested crowns survived the cyclic loading simulation of 5 years clinical use.Conclusions AM-RC showed high manufacturing accuracy and adaptation. The tested resin-based CAD/CAM materials demonstrated clinically acceptable manufacturing accuracy and simulated medium-term durability, justifying the initiation of clinical investigations to determine their potential implementation in daily clinical practice.en600 - Technology::610 - Medicine & healthManufacturing Accuracy, Intaglio Surface Adaptation, and Survival of Additively and Subtractively Manufactured Definitive Resin Crowns After Cyclic Loading: An In Vitro Study.article10.48620/875753878758210.11607/ijp.8976