Ajeje, Eduarda TebetEduarda TebetAjejeGandolfi, Joelma VillafanhaJoelma VillafanhaGandolfiCavallari, ViniciusViniciusCavallariSilva-Jr, João ManoelJoão ManoelSilva-Jrde Freitas Chaves, Renato CarneiroRenato Carneirode Freitas ChavesBerger-Estilita, Joana MartaJoana MartaBerger-EstilitaLobo, Suzana MargarethSuzana MargarethLobo2024-10-262024-10-262024-06https://boris-portal.unibe.ch/handle/20.500.12422/174332BACKGROUND Acute Gastrointestinal Injury (AGI) is associated with adverse clinical outcomes, including increased mortality. We aimed to investigate the potential of citrulline and intestinal fatty acid binding protein (I-FABP) as biomarkers for early AGI diagnosis and predicting outcomes in surgical patients. METHODS Prospective cohort study involving patients who underwent non-cardiac surgeries and were admitted to Intensive Care Units. AGI diagnosis was based on specific criteria, and severity was categorised following established guidelines. Statistical analyses were performed to assess the diagnostic accuracy of the biomarkers and their association with outcomes, P significant when <0.05. RESULTS AGI was identified in 40.3% of patients with varying severity. Mortality rates were significantly higher in the AGI group in the ICU (19.4% vs. 0%, p = 0.001) and hospital (22.6% vs. 2.17%, p = 0.003). Urinary I-FABP levels on days 3 and 7 showed reasonable and good accuracy for AGI diagnosis (AUC 0.732 and 0.813, respectively). Urinary I-FABP levels on days 2 and 3 accurately predict sepsis. Urinary citrulline levels on day one predicted mortality (AUC 0.87) furthermore urinary I-FABP levels on day 2 showed reasonable accuracy (sensitivity 83.3%, specificity 92.4%). CONCLUSION Urinary I-FABP and citrulline levels are promising diagnostic and prognostic markers in ICU patients following non-cardiac surgeries.enAcute gastrointestinal injury Biomarkers Citrulline Gastrointestinal I-FABP600 - Technology::610 - Medicine & healtharticle10.48350/1927843833586210.1016/j.jcrc.2024.154530