von Graffenried, TheaTheavon GraffenriedSafroneeva, EkaterinaEkaterinaSafroneevaBraegger, ChristianChristianBraeggerEzri, JessicaJessicaEzriGarzoni, LucaLucaGarzoniGiroud Rivier, AlexaAlexaGiroud RivierGreuter, ThomasThomasGreuterKöhler, HenrikHenrikKöhlerMcLin, Valerie AValerie AMcLinMarx, GeorgeGeorgeMarxMüller, PascalPascalMüllerPetit, Laetitia MarieLaetitia MariePetitSchibli, SusanneSusanneSchibliSokollik, ChristianeChristianeSokollik0000-0002-5992-8247Tempia-Caliera, MichelaMichelaTempia-CalieraZwahlen, MarcelMarcelZwahlen0000-0002-6772-6346Schoepfer, Alain MAlain MSchoepferNydegger, AndreasAndreasNydegger2024-10-262024-10-262024-03-06https://boris-portal.unibe.ch/handle/20.500.12422/175263INTRODUCTION Given the lack of data, we aimed to explore which therapeutic endpoints pediatric patients with eosinophilic esophagitis (EoE) and their parents consider to be relevant. METHODS We created an educational brochure on EoE and a questionnaire, both of which were content-validated by pediatric patients and parents. Validated documents were sent to 112 patients and parents. They ranked the importance (5 levels) of short (during next 3 months) and long-term (≥1 year) treatment effect on symptoms, quality of life, endoscopic inflammation, stricture formation, histological inflammation, and fibrosis. RESULTS A total of 45 parents and 30 pediatric patients ≥11 years completed the questionnaires. Pediatric patients identified improvement in the following domains as most important in the short- and long-term, respectively: symptoms (73% vs. 77%), QoL (53% vs. 57%), histologic inflammation (47% vs. 50%), histologic fibrosis (40% vs. 33%), endoscopic inflammation (47% vs. 40%), and strictures (33% vs. 40%). Parents of children ≥11 years old classified improvement in the following domains as most important in the short- and long-term, respectively: symptoms (70% vs. 83%), QoL (63% vs. 80%), histologic inflammation (67% vs. 77%), histologic fibrosis (47% vs. 63%), endoscopic inflammation (77% vs. 80%), and strictures (40% vs. 53%). Agreement between caregiver and children on the short-term importance of treatment outcomes was as follows: symptoms (77%), QoL (40%), histologic inflammation and fibrosis (47% and 43%), endoscopic inflammation and strictures (50% and 40%). CONCLUSION Pediatric patients and parents attributed most importance to improvement in symptoms and QoL. Agreement between parents and patients regarding therapy goals is limited.enCore outcome set Endpoints Eosinophilic esophagitis Parents’ perspective Pediatric patients’ perspective Therapy goals600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.48350/1939273844754810.1159/000535242