Munk, Marion RMarion RMunkZimmermann, HelenaHelenaZimmermannBerger, Lieselotte ErikaLieselotte ErikaBergerHuf, WolfgangWolfgangHufEbneter, AndreasAndreasEbneter0000-0001-6666-2558Wolf, SebastianSebastianWolf0000-0002-7467-7028Zinkernagel, Martin SebastianMartin SebastianZinkernagel0000-0003-3447-23592024-10-252024-10-252017https://boris-portal.unibe.ch/handle/20.500.12422/154588PURPOSE To compare the quality of four OCT-angiography(OCT-A) modules. METHOD The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment, a consensus grading was performed and the modules were ranked based on their scoring. RESULTS There was no significant difference in the vessel density among the modules (Zeiss 48.7±4%, Optovue 47.9±3%, Topcon 48.3±2%, Heidelberg 46.5±4%, p = 0.2). The numbers of discernible vessel-bifurcations differed significantly on each module (Zeiss 2±0.9 bifurcations, Optovue 2.5±1.2, Topcon 1.3±0.7 and Heidelberg 0.5±0.6, p≤0.001). The ranking of each module differed depending on the evaluated parameter. In the overall ranking, the Zeiss module was superior and in 90% better than the median (Bonferroni corrected p-value = 0.04). Optovue was better than the median in 60%, Topcon in 40% and Heidelberg module in 10%, however these differences were not statistically significant. CONCLUSION Each of the four evaluated OCT-A modules had particular strengths, which differentiated it from their competitors.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.1055542848991810.1371/journal.pone.0177059