Datta, Alexandre NAlexandre NDattaFurrer, Mark AMark AFurrerBernhardt, IrisIrisBernhardtHüppi, Petra SPetra SHüppiBorradori-Tolsa, CristinaCristinaBorradori-TolsaBucher, Hans UlrichHans UlrichBucherLatal, BeatriceBeatriceLatalGrunt, SebastianSebastianGruntNatalucci, GiancarloGiancarloNatalucci2024-10-252024-10-252017-06https://boris-portal.unibe.ch/handle/20.500.12422/158065AIM This study assessed predictive values of fidgety movement assessment (FMA) in a large sample of infants born very preterm for developmental abnormalities, in particular for cerebral palsy (CP) at 2 years in an everyday clinical setting. METHOD This is a multicentre study of infants born preterm with gestational age lower than 32.0 weeks. FMA was performed at 3 months corrected age; neurodevelopment (Bayley Scales of Infant Development, 2nd edition) and neurological abnormalities were assessed at 2 years. Predictive values of FMA for the development of CP were calculated and combined with abnormalities at cerebral ultrasound. RESULTS Five hundred and thirty-five infants (gestational age 28.2wks [standard deviation 1.3wks]) were included. Eighty-one percent showed normal fidgety movements and 19% atypical (82 absent, 21 abnormal) fidgety movements. Absent fidgety movements predicted CP at 2 years with an odds ratio (OR) of 8.9 (95% confidence interval [CI] 4.1-17.0), a combination of atypical fidgety movements and major brain lesion on cerebral ultrasound predicted it with an OR of 17.8 (95% CI 5.2-61.6). Mean mental developmental index of infants with absent fidgety movements was significantly lower (p=0.012) than with normal fidgety movements. INTERPRETATION Detection of infants at risk for later CP through FMA was good, but less robust when performed in a routine clinical setting; prediction improved when combined with neonatal cerebral ultrasound.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.1108832810257410.1111/dmcn.13386