Ricketts, Christopher JChristopher JRickettsDe Cubas, Aguirre AAguirre ADe CubasFan, HuihuiHuihuiFanSmith, Christof CChristof CSmithLang, MartinMartinLangReznik, EdEdReznikBowlby, ReanneReanneBowlbyGibb, Ewan AEwan AGibbAkbani, RehanRehanAkbaniBeroukhim, RameenRameenBeroukhimBottaro, Donald PDonald PBottaroChoueiri, Toni KToni KChoueiriGibbs, Richard ARichard AGibbsGodwin, Andrew KAndrew KGodwinHaake, ScottScottHaakeHakimi, A AriA AriHakimiHenske, Elizabeth PElizabeth PHenskeHsieh, James JJames JHsiehHo, Thai HThai HHoKanchi, Rupa SRupa SKanchiKrishnan, BhavaniBhavaniKrishnanKwiatkowski, David JDavid JKwiatkowskiLui, WembinWembinLuiMerino, Maria JMaria JMerinoMills, Gordon BGordon BMillsMyers, JeromeJeromeMyersNickerson, Michael LMichael LNickersonReuter, Victor EVictor EReuterSchmidt, Laura SLaura SSchmidtShelley, C SimonC SimonShelleyShen, HuiHuiShenShuch, BrianBrianShuchSignoretti, SabinaSabinaSignorettiSrinivasan, RamaprasadRamaprasadSrinivasanTamboli, PherozePherozeTamboliThomas, GeorgeGeorgeThomasVincent, Benjamin GBenjamin GVincentVocke, Cathy DCathy DVockeWheeler, David ADavid AWheelerYang, LixingLixingYangKim, William YWilliam YKimRobertson, A GordonA GordonRobertsonSpellman, Paul TPaul TSpellmanRathmell, W KimrynW KimrynRathmellLinehan, W MarstonW MarstonLinehan2024-10-082024-10-082018-04-03https://boris-portal.unibe.ch/handle/20.500.12422/64163Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.enCDKN2A DNA hypermethylation PanCanAtlas TCGA chromatin remodeling chromophobe renal cell carcinoma clear cell renal cell carcinoma immune signature papillary renal cell carcinoma600 - Technology::610 - Medicine & healtharticle10.7892/boris.1263792961766910.1016/j.celrep.2018.03.075