Combes, Jean-DamienJean-DamienCombesClifford, Gary MGary MCliffordEgger, MatthiasMatthiasEgger0000-0001-7462-5132Cavassini, MatthiasMatthiasCavassiniHirsch, Hans HHans HHirschHauser, Christoph VictorChristoph VictorHauser0000-0002-2413-8931Calmy, AlexandraAlexandraCalmySchmid, PatrickPatrickSchmidBernasconi, EnosEnosBernasconiGünthard, Huldrych FHuldrych FGünthardFranceschi, SilviaSilviaFranceschiWaterboer, TimTimWaterboerScherrer, Alexandra UAlexandra UScherrerSwiss HIV Cohort, StudyStudySwiss HIV Cohort2024-10-242024-10-242017-02-20https://boris-portal.unibe.ch/handle/20.500.12422/149420OBJECTIVE To describe effects of HAART on high-risk human papillomavirus (HPV) antibody response in HIV-positive MSM and the meaning of this response for subsequent HPV-related cancer risk. DESIGN Prospective seroepidemiological study of 281 HIV-positive MSM initiating HAART between 1995 and 2004 in the Swiss HIV Cohort Study. METHODS For each individual, two serum samples, one at HAART initiation (pre-HAART) and another 24 months later (post-HAART), were tested for L1 antibodies to HPV6, 11, 16, 18, 31, 33, 35, 45, 52 and 58, as well as HPV16-E6 antibodies, using a multiplex serology assay. Identification of HPV-related cancer included data linkage with Swiss cancer registries. RESULTS Pre-HAART, 45.2% were seropositive for any high-risk HPV-L1 and 32.4% for HPV16-L1. Sexual intercourse during the last 6 months was the only evaluated factor associated with L1 seropositivity pre-HAART. Seropositivity increased post-HAART to 60.5% for any high-risk HPV-L1 [prevalence ratio versus pre-HAART = 1.34, 95% confidence interval (CI) 1.14-1.57] and 48.0% for HPV16-L1 (prevalence ratio versus pre-HAART = 1.48, 95% CI 1.20-1.83), and seroconversion was significantly associated with both lower CD4 cell count and CD4/CD8 ratio (P < 0.01). Only one individual was HPV16-E6-seropositive pre-HAART, but two more seroconverted post-HAART. Anal cancer incidence among the three HPV16-E6-positives post-HAART was significantly increased compared with HPV16-E6-negatives (incidence rate ratio = 63.1, 95% CI 1.1-1211). CONCLUSION HAART-related immune reconstitution increases HPV-specific antibody responses, which may discriminate future anal cancer risk in this high-risk population.en600 - Technology::610 - Medicine & health300 - Social sciences, sociology & anthropology::360 - Social problems & social servicesarticle10.7892/boris.948622812166910.1097/QAD.0000000000001354