Christophersen, Ingrid EIngrid EChristophersenRienstra, MichielMichielRienstraRoselli, CarolinaCarolinaRoselliYin, XiaoyanXiaoyanYinGeelhoed, BastiaanBastiaanGeelhoedBarnard, JohnJohnBarnardLin, HonghuangHonghuangLinArking, Dan EDan EArkingSmith, Albert VAlbert VSmithAlbert, Christine MChristine MAlbertChaffin, MarkMarkChaffinTucker, Nathan RNathan RTuckerLi, MolongMolongLiKlarin, DerekDerekKlarinBihlmeyer, Nathan ANathan ABihlmeyerLow, Siew-KeeSiew-KeeLowWeeke, Peter EPeter EWeekeMüller-Nurasyid, MartinaMartinaMüller-NurasyidSmith, J GustavJ GustavSmithBrody, Jennifer AJennifer ABrodyNiemeijer, Maartje NMaartje NNiemeijerDörr, MarcusMarcusDörrTrompet, StellaStellaTrompetHuffman, JenniferJenniferHuffmanGustafsson, StefanStefanGustafssonSchurmann, ClaudiaClaudiaSchurmannKleber, Marcus EMarcus EKleberLyytikäinen, Leo-PekkaLeo-PekkaLyytikäinenSeppälä, IlkkaIlkkaSeppäläMalik, RainerRainerMalikHorimoto, Andrea R V RAndrea R V RHorimotoPerez, MarcoMarcoPerezSinisalo, JuhaJuhaSinisaloAeschbacher, StefanieStefanieAeschbacherThériault, SébastienSébastienThériaultYao, JieJieYaoRadmanesh, FaridFaridRadmaneshWeiss, StefanStefanWeissTeumer, AlexanderAlexanderTeumerChoi, Seung HoanSeung HoanChoiWeng, Lu-ChenLu-ChenWengClauss, SebastianSebastianClaussDeo, RajatRajatDeoRader, Daniel JDaniel JRaderShah, Svati HSvati HShahSun, AlbertAlbertSunHopewell, Jemma CJemma CHopewellDebette, StephanieStephanieDebetteChauhan, GaneshGaneshChauhanYang, QiongQiongYangWorrall, Bradford BBradford BWorrallParé, GuillaumeGuillaumeParéKamatani, YoichiroYoichiroKamataniHagemeijer, Yanick PYanick PHagemeijerVerweij, NiekNiekVerweijSiland, Joylene EJoylene ESilandKubo, MichiakiMichiakiKuboSmith, Jonathan DJonathan DSmithVan Wagoner, David RDavid RVan WagonerBis, Joshua CJoshua CBisPerz, SiegfriedSiegfriedPerzPsaty, Bruce MBruce MPsatyRidker, Paul MPaul MRidkerMagnani, Jared WJared WMagnaniHarris, Tamara BTamara BHarrisLauner, Lenore JLenore JLaunerShoemaker, M BenjaminM BenjaminShoemakerPadmanabhan, SandoshSandoshPadmanabhanHaessler, JeffreyJeffreyHaesslerBartz, Traci MTraci MBartzWaldenberger, MelanieMelanieWaldenbergerLichtner, PeterPeterLichtnerArendt, MarinaMarinaArendtKrieger, Jose EJose EKriegerKähönen, MikaMikaKähönenRisch, LorenzLorenzRisch0000-0003-2692-6699Mansur, Alfredo JAlfredo JMansurPeters, AnnetteAnnettePetersSmith, Blair HBlair HSmithLind, LarsLarsLindScott, Stuart AStuart AScottLu, YingchangYingchangLuBottinger, Erwin BErwin BBottingerHernesniemi, JussiJussiHernesniemiLindgren, Cecilia MCecilia MLindgrenWong, Jorge AJorge AWongHuang, JieJieHuangEskola, MarkkuMarkkuEskolaMorris, Andrew PAndrew PMorrisFord, IanIanFordReiner, Alex PAlex PReinerDelgado, GracielaGracielaDelgadoChen, Lin YLin YChenChen, Yii-Der IdaYii-Der IdaChenSandhu, Roopinder KRoopinder KSandhuLi, ManManLiBoerwinkle, EricEricBoerwinkleEisele, LewinLewinEiseleLannfelt, LarsLarsLannfeltRost, NataliaNataliaRostAnderson, Christopher DChristopher DAndersonTaylor, Kent DKent DTaylorCampbell, ArchieArchieCampbellMagnusson, Patrik KPatrik KMagnussonPorteous, DavidDavidPorteousHocking, Lynne JLynne JHockingVlachopoulou, EfthymiaEfthymiaVlachopoulouPedersen, Nancy LNancy LPedersenNikus, KjellKjellNikusOrho-Melander, MarjuMarjuOrho-MelanderHamsten, AndersAndersHamstenHeeringa, JanJanHeeringaDenny, Joshua CJoshua CDennyKriebel, JenniferJenniferKriebelDarbar, DawoodDawoodDarbarNewton-Cheh, ChristopherChristopherNewton-ChehShaffer, ChristianChristianShafferMacfarlane, Peter WPeter WMacfarlaneHeilmann-Heimbach, StefanieStefanieHeilmann-HeimbachAlmgren, PeterPeterAlmgrenHuang, Paul LPaul LHuangSotoodehnia, NonaNonaSotoodehniaSoliman, Elsayed ZElsayed ZSolimanUitterlinden, Andre GAndre GUitterlindenHofman, AlbertAlbertHofmanFranco, Oscar HOscar HFrancoVölker, UweUweVölkerJöckel, Karl-HeinzKarl-HeinzJöckelSinner, Moritz FMoritz FSinnerLin, Henry JHenry JLinGuo, XiuqingXiuqingGuoDichgans, MartinMartinDichgansIngelsson, ErikErikIngelssonKooperberg, CharlesCharlesKooperbergMelander, OlleOlleMelanderLoos, Ruth J FRuth J FLoosLaurikka, JariJariLaurikkaConen, DavidDavidConenRosand, JonathanJonathanRosandvan der Harst, PimPimvan der HarstLokki, Marja-LiisaMarja-LiisaLokkiKathiresan, SekarSekarKathiresanPereira, AlexandreAlexandrePereiraJukema, J WouterJ WouterJukemaHayward, CarolineCarolineHaywardRotter, Jerome IJerome IRotterMärz, WinfriedWinfriedMärzLehtimäki, TerhoTerhoLehtimäkiStricker, Bruno HBruno HStrickerChung, Mina KMina KChungFelix, Stephan BStephan BFelixGudnason, VilmundurVilmundurGudnasonAlonso, AlvaroAlvaroAlonsoRoden, Dan MDan MRodenKääb, StefanStefanKääbChasman, Daniel IDaniel IChasmanHeckbert, Susan RSusan RHeckbertBenjamin, Emelia JEmelia JBenjaminTanaka, ToshihiroToshihiroTanakaLunetta, Kathryn LKathryn LLunettaLubitz, Steven ASteven ALubitzEllinor, Patrick TPatrick TEllinor2024-10-252024-10-252017-06https://boris-portal.unibe.ch/handle/20.500.12422/159125Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery.en600 - Technology::610 - Medicine & healtharticle10.7892/boris.1124932841681810.1038/ng.3843